Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species

Verbiest, Max; Maksimov, Mikhail; Jin, Ye; Anisimova, Maria; Gymrek, Melissa; Bilgin Sonay, Tugce

doi:10.1111/jeb.14106

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26057

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species
Authors:	Verbiest, Max Maksimov, Mikhail Jin, Ye Anisimova, Maria Gymrek, Melissa Bilgin Sonay, Tugce
et. al:	No
DOI:	10.1111/jeb.14106 10.21256/zhaw-26057
Published in:	Journal of Evolutionary Biology
Volume(Issue):	36
Issue:	2
Page(s):	321
Pages to:	336
Issue Date:	26-Oct-2022
Publisher / Ed. Institution:	Wiley
ISSN:	1010-061X 1420-9101
Language:	English
Subjects:	DNA repair; Complex traits; Evolution; Microsatellite; Selection; Short tandem repeats
Subject (DDC):	572: Biochemistry
Abstract:	Short tandem repeats (STRs) are units of 1-6 bp that repeat in a tandem fashion in DNA. Along with single nucleotide polymorphisms and large structural variations, they are among the major genomic variants underlying genetic, and likely phenotypic, divergence. STRs experience mutation rates that are orders of magnitude higher than other well-studied genotypic variants. Frequent copy number changes result in a wide range of alleles, and provide unique opportunities for modulating complex phenotypes through variation in repeat length. While classical studies have identified key roles of individual STR loci, the advent of improved sequencing technology, high-quality genome assemblies for diverse species, and bioinformatics methods for genome-wide STR analysis now enable more systematic study of STR variation across wide evolutionary ranges. In this review, we explore mutation and selection processes that affect STR copy number evolution, and how these processes give rise to varying STR patterns both within and across species. Finally, we review recent examples of functional and adaptive changes linked to STRs.
URI:	https://digitalcollection.zhaw.ch/handle/11475/26057
Related research data:	https://doi.org/10.6084/m9.figshare.20520723.v2 https://doi.org/10.5281/zenodo.7011508
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Computational Life Sciences (ICLS)
Published as part of the ZHAW project:	Trans-omic approach to colorectal cancer: an integrative computational and clinical perspective REFRACT – Repeat protein Function, Refinement, Annotation and Classification of Topologies
Appears in collections:	Publikationen Life Sciences und Facility Management

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Verbiest, M., Maksimov, M., Jin, Y., Anisimova, M., Gymrek, M., & Bilgin Sonay, T. (2022). Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species. Journal of Evolutionary Biology, 36(2), 321–336. https://doi.org/10.1111/jeb.14106

Verbiest, M. et al. (2022) ‘Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species’, Journal of Evolutionary Biology, 36(2), pp. 321–336. Available at: https://doi.org/10.1111/jeb.14106.

M. Verbiest, M. Maksimov, Y. Jin, M. Anisimova, M. Gymrek, and T. Bilgin Sonay, “Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species,” Journal of Evolutionary Biology, vol. 36, no. 2, pp. 321–336, Oct. 2022, doi: 10.1111/jeb.14106.

VERBIEST, Max, Mikhail MAKSIMOV, Ye JIN, Maria ANISIMOVA, Melissa GYMREK und Tugce BILGIN SONAY, 2022. Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species. Journal of Evolutionary Biology. 26 Oktober 2022. Bd. 36, Nr. 2, S. 321–336. DOI 10.1111/jeb.14106

Verbiest, Max, Mikhail Maksimov, Ye Jin, Maria Anisimova, Melissa Gymrek, and Tugce Bilgin Sonay. 2022. “Mutation and Selection Processes Regulating Short Tandem Repeats Give Rise to Genetic and Phenotypic Diversity across Species.” Journal of Evolutionary Biology 36 (2): 321–36. https://doi.org/10.1111/jeb.14106.

Verbiest, Max, et al. “Mutation and Selection Processes Regulating Short Tandem Repeats Give Rise to Genetic and Phenotypic Diversity across Species.” Journal of Evolutionary Biology, vol. 36, no. 2, Oct. 2022, pp. 321–36, https://doi.org/10.1111/jeb.14106.