Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26057
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dc.contributor.authorVerbiest, Max-
dc.contributor.authorMaksimov, Mikhail-
dc.contributor.authorJin, Ye-
dc.contributor.authorAnisimova, Maria-
dc.contributor.authorGymrek, Melissa-
dc.contributor.authorBilgin Sonay, Tugce-
dc.date.accessioned2022-11-11T14:51:34Z-
dc.date.available2022-11-11T14:51:34Z-
dc.date.issued2022-10-26-
dc.identifier.issn1010-061Xde_CH
dc.identifier.issn1420-9101de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26057-
dc.description.abstractShort tandem repeats (STRs) are units of 1-6 bp that repeat in a tandem fashion in DNA. Along with single nucleotide polymorphisms and large structural variations, they are among the major genomic variants underlying genetic, and likely phenotypic, divergence. STRs experience mutation rates that are orders of magnitude higher than other well-studied genotypic variants. Frequent copy number changes result in a wide range of alleles, and provide unique opportunities for modulating complex phenotypes through variation in repeat length. While classical studies have identified key roles of individual STR loci, the advent of improved sequencing technology, high-quality genome assemblies for diverse species, and bioinformatics methods for genome-wide STR analysis now enable more systematic study of STR variation across wide evolutionary ranges. In this review, we explore mutation and selection processes that affect STR copy number evolution, and how these processes give rise to varying STR patterns both within and across species. Finally, we review recent examples of functional and adaptive changes linked to STRs.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofJournal of Evolutionary Biologyde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectDNA repairde_CH
dc.subjectComplex traitsde_CH
dc.subjectEvolutionde_CH
dc.subjectMicrosatellitede_CH
dc.subjectSelectionde_CH
dc.subjectShort tandem repeatsde_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleMutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across speciesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1111/jeb.14106de_CH
dc.identifier.doi10.21256/zhaw-26057-
dc.identifier.pmid36289560de_CH
zhaw.funding.euinfo:eu-repo/grantAgreement/EC/H2020/823886//Repeat protein Function Refinement, Annotation and Classification of Topologies/REFRACTde_CH
zhaw.issue2de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end336de_CH
zhaw.pages.start321de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume36de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.funding.snf193832, 203264de_CH
zhaw.webfeedComputational Genomicsde_CH
zhaw.funding.zhawTrans-omic approach to colorectal cancer: an integrative computational and clinical perspectivede_CH
zhaw.funding.zhawREFRACT – Repeat protein Function, Refinement, Annotation and Classification of Topologiesde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
zhaw.relation.referenceshttps://doi.org/10.6084/m9.figshare.20520723.v2de_CH
zhaw.relation.referenceshttps://doi.org/10.5281/zenodo.7011508de_CH
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Verbiest, M., Maksimov, M., Jin, Y., Anisimova, M., Gymrek, M., & Bilgin Sonay, T. (2022). Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species. Journal of Evolutionary Biology, 36(2), 321–336. https://doi.org/10.1111/jeb.14106
Verbiest, M. et al. (2022) ‘Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species’, Journal of Evolutionary Biology, 36(2), pp. 321–336. Available at: https://doi.org/10.1111/jeb.14106.
M. Verbiest, M. Maksimov, Y. Jin, M. Anisimova, M. Gymrek, and T. Bilgin Sonay, “Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species,” Journal of Evolutionary Biology, vol. 36, no. 2, pp. 321–336, Oct. 2022, doi: 10.1111/jeb.14106.
VERBIEST, Max, Mikhail MAKSIMOV, Ye JIN, Maria ANISIMOVA, Melissa GYMREK und Tugce BILGIN SONAY, 2022. Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species. Journal of Evolutionary Biology. 26 Oktober 2022. Bd. 36, Nr. 2, S. 321–336. DOI 10.1111/jeb.14106
Verbiest, Max, Mikhail Maksimov, Ye Jin, Maria Anisimova, Melissa Gymrek, and Tugce Bilgin Sonay. 2022. “Mutation and Selection Processes Regulating Short Tandem Repeats Give Rise to Genetic and Phenotypic Diversity across Species.” Journal of Evolutionary Biology 36 (2): 321–36. https://doi.org/10.1111/jeb.14106.
Verbiest, Max, et al. “Mutation and Selection Processes Regulating Short Tandem Repeats Give Rise to Genetic and Phenotypic Diversity across Species.” Journal of Evolutionary Biology, vol. 36, no. 2, Oct. 2022, pp. 321–36, https://doi.org/10.1111/jeb.14106.


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