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https://doi.org/10.21256/zhaw-26057| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species |
| Autor/-in: | Verbiest, Max Maksimov, Mikhail Jin, Ye Anisimova, Maria Gymrek, Melissa Bilgin Sonay, Tugce |
| et. al: | No |
| DOI: | 10.1111/jeb.14106 10.21256/zhaw-26057 |
| Erschienen in: | Journal of Evolutionary Biology |
| Band(Heft): | 36 |
| Heft: | 2 |
| Seite(n): | 321 |
| Seiten bis: | 336 |
| Erscheinungsdatum: | 26-Okt-2022 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 1010-061X 1420-9101 |
| Sprache: | Englisch |
| Schlagwörter: | DNA repair; Complex traits; Evolution; Microsatellite; Selection; Short tandem repeats |
| Fachgebiet (DDC): | 572: Biochemie |
| Zusammenfassung: | Short tandem repeats (STRs) are units of 1-6 bp that repeat in a tandem fashion in DNA. Along with single nucleotide polymorphisms and large structural variations, they are among the major genomic variants underlying genetic, and likely phenotypic, divergence. STRs experience mutation rates that are orders of magnitude higher than other well-studied genotypic variants. Frequent copy number changes result in a wide range of alleles, and provide unique opportunities for modulating complex phenotypes through variation in repeat length. While classical studies have identified key roles of individual STR loci, the advent of improved sequencing technology, high-quality genome assemblies for diverse species, and bioinformatics methods for genome-wide STR analysis now enable more systematic study of STR variation across wide evolutionary ranges. In this review, we explore mutation and selection processes that affect STR copy number evolution, and how these processes give rise to varying STR patterns both within and across species. Finally, we review recent examples of functional and adaptive changes linked to STRs. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/26057 |
| Zugehörige Forschungsdaten: | https://doi.org/10.6084/m9.figshare.20520723.v2 https://doi.org/10.5281/zenodo.7011508 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Computational Life Sciences (ICLS) |
| Publiziert im Rahmen des ZHAW-Projekts: | Trans-omic approach to colorectal cancer: an integrative computational and clinical perspective REFRACT – Repeat protein Function, Refinement, Annotation and Classification of Topologies |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2022_Verbiest-etal_Mutation-selection-processes-short-tandem-repeats.pdf | 1.48 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Verbiest, M., Maksimov, M., Jin, Y., Anisimova, M., Gymrek, M., & Bilgin Sonay, T. (2022). Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species. Journal of Evolutionary Biology, 36(2), 321–336. https://doi.org/10.1111/jeb.14106
Verbiest, M. et al. (2022) ‘Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species’, Journal of Evolutionary Biology, 36(2), pp. 321–336. Available at: https://doi.org/10.1111/jeb.14106.
M. Verbiest, M. Maksimov, Y. Jin, M. Anisimova, M. Gymrek, and T. Bilgin Sonay, “Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species,” Journal of Evolutionary Biology, vol. 36, no. 2, pp. 321–336, Oct. 2022, doi: 10.1111/jeb.14106.
VERBIEST, Max, Mikhail MAKSIMOV, Ye JIN, Maria ANISIMOVA, Melissa GYMREK und Tugce BILGIN SONAY, 2022. Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species. Journal of Evolutionary Biology. 26 Oktober 2022. Bd. 36, Nr. 2, S. 321–336. DOI 10.1111/jeb.14106
Verbiest, Max, Mikhail Maksimov, Ye Jin, Maria Anisimova, Melissa Gymrek, and Tugce Bilgin Sonay. 2022. “Mutation and Selection Processes Regulating Short Tandem Repeats Give Rise to Genetic and Phenotypic Diversity across Species.” Journal of Evolutionary Biology 36 (2): 321–36. https://doi.org/10.1111/jeb.14106.
Verbiest, Max, et al. “Mutation and Selection Processes Regulating Short Tandem Repeats Give Rise to Genetic and Phenotypic Diversity across Species.” Journal of Evolutionary Biology, vol. 36, no. 2, Oct. 2022, pp. 321–36, https://doi.org/10.1111/jeb.14106.
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