Human adipose stem cells (hASCs) are promising candidates for cell-based therapies, but they need to be efficiently expanded in vitro as they cannot be harvested in sufficient quantities. Recently, dynamic bioreactor systems operated with microcarriers achieved considerable high cell densities. Thus, they are a viable alternative to static planar cultivation systems to obtain high numbers of clinical-grade hASCs. Nevertheless, the production of considerable biomass in a short time must not be achieved to the detriment of the cells’ quality. To facilitate the scalable expansion of hASC, we have developed a new serum- and xeno-free medium (UrSuppe) and a biodegradable microcarrier (BR44). In this study, we investigated whether the culture of hASCs in defined serum-free conditions on microcarriers (3D) or on planar (2D) cell culture vessels may influence the expression of some marker genes linked with the immature degree or the differentiated status of the cells. Furthermore, we invest...
Die 35-jährige Richterin Johanna Müller entwickelt eine Woche nach einem Autounfall Kopf- und Nackenschmerzen, Schwindel, massive Konzentrationsstörungen und Augenprobleme. Nach einem ausführlichen Befund konzentriert sich ihr Physiotherapeut auf Edukation und Hands-off-Therapien – mit Erfolg.
In the entire “new work” area agility is highly requested. Beyond the normative idea of agility, which itself is not well defined, the concept has some fundamental psychological implications. It’s one of the main insights from our research, that agility needs to come in harmony with reflection and personal development. We see a strong need to strengthen psychological resources in order to get agility functional as well as psychologically sustainable. In the workshop we aim to work on some fundamental aspects of personal and team related learning pathways to agility.
In the past decades, the search for a more sustainable way of global development has increased in importance in international politics and economy. A driving force is the continuing degradation of the environment in many areas of the world, often caused or accelerated by population growth and climate change. Sustainable development is seen as key approach to mitigate these processes. It has been defined as “development that meets the needs of the present without compromising the ability of future generations to meet their own needs.” But how can this ambitious goal be achieved in the light of numerous global challenges? Engineering is a very influential human practice and must be addressed in this context. Engineers are crucially involved in design and construction of our built environment and thus in shaping almost its entire development. However, when designing a solution for a given problem, effects caused outside of the system borders are often not considered. If this is combine...
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