Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products

Kern, Susanne; Dkhil, Hafida; Hendarsa, Prisca; Ellis, Graham; Natsch, Andreas

doi:10.1007/s00216-014-8066-3

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products
Authors:	Kern, Susanne Dkhil, Hafida Hendarsa, Prisca Ellis, Graham Natsch, Andreas
et. al:	No
DOI:	10.1007/s00216-014-8066-3
Published in:	Analytical and Bioanalytical Chemistry
Volume(Issue):	406
Issue:	25
Page(s):	6165
Pages to:	6178
Issue Date:	Oct-2014
Publisher / Ed. Institution:	Springer
ISSN:	1618-2642 1618-2650
Language:	English
Subjects:	Acyclic monoterpenes; Antiperspirant; Liquid chromatography; Human; Hydrogen peroxide; Mass spectrometry; Molecular structure; Monoterpene; Oxidation-reduction; Perfume; Skin
Subject (DDC):	540: Chemistry
Abstract:	On prolonged exposure to air, linalool can form sensitizing hydroperoxides. Positive hydroperoxide patch tests in dermatitis patients have frequently been reported, but their relevance has not been established. Owing to a lack of analytical methods and data, it is unclear from which sources the public might be exposed to sufficient quantities of hydroperoxides for induction of sensitization to occur. To address this knowledge gap, we developed analytical methods and performed stability studies for fine fragrances and deodorants/antiperspirants. In parallel, products recalled from consumers were analysed to investigate exposure to products used in everyday life. Liquid chromatography-mass spectrometry with high mass resolution was found to be optimal for the selective and sensitive detection of the organic hydroperoxide in the complex product matrix. Linalool hydroperoxide was detected in natural linalool, but the amount was not elevated by storage in a perfume formulation exposed to air. No indication of hydroperoxide formation in fine fragrances was found in stability studies. Aged fine fragrances recalled from consumers contained a geometric mean linalool concentration of 1,888 μg/g and, corrected for matrix effects, linalool hydroperoxide at a concentration of around 14 μg/g. In antiperspirants, we detected no oxidation products. In conclusion, very low levels of linalool hydroperoxide in fragranced products may originate from raw materials, but we found no evidence for oxidation during storage of products. The levels detected are orders of magnitude below the levels inducing sensitization in experimental animals, and these results therefore do not substantiate a causal link between potential hydroperoxide formation in cosmetics and positive results of patch tests.
URI:	https://digitalcollection.zhaw.ch/handle/11475/23985
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

Files in This Item:

There are no files associated with this item.

Show full item record

Kern, S., Dkhil, H., Hendarsa, P., Ellis, G., & Natsch, A. (2014). Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products. Analytical and Bioanalytical Chemistry, 406(25), 6165–6178. https://doi.org/10.1007/s00216-014-8066-3

Kern, S. et al. (2014) ‘Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products’, Analytical and Bioanalytical Chemistry, 406(25), pp. 6165–6178. Available at: https://doi.org/10.1007/s00216-014-8066-3.

S. Kern, H. Dkhil, P. Hendarsa, G. Ellis, and A. Natsch, “Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products,” Analytical and Bioanalytical Chemistry, vol. 406, no. 25, pp. 6165–6178, Oct. 2014, doi: 10.1007/s00216-014-8066-3.

KERN, Susanne, Hafida DKHIL, Prisca HENDARSA, Graham ELLIS und Andreas NATSCH, 2014. Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products. Analytical and Bioanalytical Chemistry. Oktober 2014. Bd. 406, Nr. 25, S. 6165–6178. DOI 10.1007/s00216-014-8066-3

Kern, Susanne, Hafida Dkhil, Prisca Hendarsa, Graham Ellis, and Andreas Natsch. 2014. “Detection of Potentially Skin Sensitizing Hydroperoxides of Linalool in Fragranced Products.” Analytical and Bioanalytical Chemistry 406 (25): 6165–78. https://doi.org/10.1007/s00216-014-8066-3.

Kern, Susanne, et al. “Detection of Potentially Skin Sensitizing Hydroperoxides of Linalool in Fragranced Products.” Analytical and Bioanalytical Chemistry, vol. 406, no. 25, Oct. 2014, pp. 6165–78, https://doi.org/10.1007/s00216-014-8066-3.