| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products |
| Autor/-in: | Kern, Susanne Dkhil, Hafida Hendarsa, Prisca Ellis, Graham Natsch, Andreas |
| et. al: | No |
| DOI: | 10.1007/s00216-014-8066-3 |
| Erschienen in: | Analytical and Bioanalytical Chemistry |
| Band(Heft): | 406 |
| Heft: | 25 |
| Seite(n): | 6165 |
| Seiten bis: | 6178 |
| Erscheinungsdatum: | Okt-2014 |
| Verlag / Hrsg. Institution: | Springer |
| ISSN: | 1618-2642 1618-2650 |
| Sprache: | Englisch |
| Schlagwörter: | Acyclic monoterpenes; Antiperspirant; Liquid chromatography; Human; Hydrogen peroxide; Mass spectrometry; Molecular structure; Monoterpene; Oxidation-reduction; Perfume; Skin |
| Fachgebiet (DDC): | 540: Chemie |
| Zusammenfassung: | On prolonged exposure to air, linalool can form sensitizing hydroperoxides. Positive hydroperoxide patch tests in dermatitis patients have frequently been reported, but their relevance has not been established. Owing to a lack of analytical methods and data, it is unclear from which sources the public might be exposed to sufficient quantities of hydroperoxides for induction of sensitization to occur. To address this knowledge gap, we developed analytical methods and performed stability studies for fine fragrances and deodorants/antiperspirants. In parallel, products recalled from consumers were analysed to investigate exposure to products used in everyday life. Liquid chromatography-mass spectrometry with high mass resolution was found to be optimal for the selective and sensitive detection of the organic hydroperoxide in the complex product matrix. Linalool hydroperoxide was detected in natural linalool, but the amount was not elevated by storage in a perfume formulation exposed to air. No indication of hydroperoxide formation in fine fragrances was found in stability studies. Aged fine fragrances recalled from consumers contained a geometric mean linalool concentration of 1,888 μg/g and, corrected for matrix effects, linalool hydroperoxide at a concentration of around 14 μg/g. In antiperspirants, we detected no oxidation products. In conclusion, very low levels of linalool hydroperoxide in fragranced products may originate from raw materials, but we found no evidence for oxidation during storage of products. The levels detected are orders of magnitude below the levels inducing sensitization in experimental animals, and these results therefore do not substantiate a causal link between potential hydroperoxide formation in cosmetics and positive results of patch tests. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/23985 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Kern, S., Dkhil, H., Hendarsa, P., Ellis, G., & Natsch, A. (2014). Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products. Analytical and Bioanalytical Chemistry, 406(25), 6165–6178. https://doi.org/10.1007/s00216-014-8066-3
Kern, S. et al. (2014) ‘Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products’, Analytical and Bioanalytical Chemistry, 406(25), pp. 6165–6178. Available at: https://doi.org/10.1007/s00216-014-8066-3.
S. Kern, H. Dkhil, P. Hendarsa, G. Ellis, and A. Natsch, “Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products,” Analytical and Bioanalytical Chemistry, vol. 406, no. 25, pp. 6165–6178, Oct. 2014, doi: 10.1007/s00216-014-8066-3.
KERN, Susanne, Hafida DKHIL, Prisca HENDARSA, Graham ELLIS und Andreas NATSCH, 2014. Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products. Analytical and Bioanalytical Chemistry. Oktober 2014. Bd. 406, Nr. 25, S. 6165–6178. DOI 10.1007/s00216-014-8066-3
Kern, Susanne, Hafida Dkhil, Prisca Hendarsa, Graham Ellis, and Andreas Natsch. 2014. “Detection of Potentially Skin Sensitizing Hydroperoxides of Linalool in Fragranced Products.” Analytical and Bioanalytical Chemistry 406 (25): 6165–78. https://doi.org/10.1007/s00216-014-8066-3.
Kern, Susanne, et al. “Detection of Potentially Skin Sensitizing Hydroperoxides of Linalool in Fragranced Products.” Analytical and Bioanalytical Chemistry, vol. 406, no. 25, Oct. 2014, pp. 6165–78, https://doi.org/10.1007/s00216-014-8066-3.
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