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dc.contributor.authorKern, Susanne-
dc.contributor.authorDkhil, Hafida-
dc.contributor.authorHendarsa, Prisca-
dc.contributor.authorEllis, Graham-
dc.contributor.authorNatsch, Andreas-
dc.date.accessioned2022-01-21T16:21:21Z-
dc.date.available2022-01-21T16:21:21Z-
dc.date.issued2014-10-
dc.identifier.issn1618-2642de_CH
dc.identifier.issn1618-2650de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/23985-
dc.description.abstractOn prolonged exposure to air, linalool can form sensitizing hydroperoxides. Positive hydroperoxide patch tests in dermatitis patients have frequently been reported, but their relevance has not been established. Owing to a lack of analytical methods and data, it is unclear from which sources the public might be exposed to sufficient quantities of hydroperoxides for induction of sensitization to occur. To address this knowledge gap, we developed analytical methods and performed stability studies for fine fragrances and deodorants/antiperspirants. In parallel, products recalled from consumers were analysed to investigate exposure to products used in everyday life. Liquid chromatography-mass spectrometry with high mass resolution was found to be optimal for the selective and sensitive detection of the organic hydroperoxide in the complex product matrix. Linalool hydroperoxide was detected in natural linalool, but the amount was not elevated by storage in a perfume formulation exposed to air. No indication of hydroperoxide formation in fine fragrances was found in stability studies. Aged fine fragrances recalled from consumers contained a geometric mean linalool concentration of 1,888 μg/g and, corrected for matrix effects, linalool hydroperoxide at a concentration of around 14 μg/g. In antiperspirants, we detected no oxidation products. In conclusion, very low levels of linalool hydroperoxide in fragranced products may originate from raw materials, but we found no evidence for oxidation during storage of products. The levels detected are orders of magnitude below the levels inducing sensitization in experimental animals, and these results therefore do not substantiate a causal link between potential hydroperoxide formation in cosmetics and positive results of patch tests.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofAnalytical and Bioanalytical Chemistryde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAcyclic monoterpenesde_CH
dc.subjectAntiperspirantde_CH
dc.subjectLiquid chromatographyde_CH
dc.subjectHumande_CH
dc.subjectHydrogen peroxidede_CH
dc.subjectMass spectrometryde_CH
dc.subjectMolecular structurede_CH
dc.subjectMonoterpenede_CH
dc.subjectOxidation-reductionde_CH
dc.subjectPerfumede_CH
dc.subjectSkinde_CH
dc.subject.ddc540: Chemiede_CH
dc.titleDetection of potentially skin sensitizing hydroperoxides of linalool in fragranced productsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1007/s00216-014-8066-3de_CH
dc.identifier.pmid25138721de_CH
zhaw.funding.euNode_CH
zhaw.issue25de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end6178de_CH
zhaw.pages.start6165de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume406de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Kern, S., Dkhil, H., Hendarsa, P., Ellis, G., & Natsch, A. (2014). Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products. Analytical and Bioanalytical Chemistry, 406(25), 6165–6178. https://doi.org/10.1007/s00216-014-8066-3
Kern, S. et al. (2014) ‘Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products’, Analytical and Bioanalytical Chemistry, 406(25), pp. 6165–6178. Available at: https://doi.org/10.1007/s00216-014-8066-3.
S. Kern, H. Dkhil, P. Hendarsa, G. Ellis, and A. Natsch, “Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products,” Analytical and Bioanalytical Chemistry, vol. 406, no. 25, pp. 6165–6178, Oct. 2014, doi: 10.1007/s00216-014-8066-3.
KERN, Susanne, Hafida DKHIL, Prisca HENDARSA, Graham ELLIS und Andreas NATSCH, 2014. Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products. Analytical and Bioanalytical Chemistry. Oktober 2014. Bd. 406, Nr. 25, S. 6165–6178. DOI 10.1007/s00216-014-8066-3
Kern, Susanne, Hafida Dkhil, Prisca Hendarsa, Graham Ellis, and Andreas Natsch. 2014. “Detection of Potentially Skin Sensitizing Hydroperoxides of Linalool in Fragranced Products.” Analytical and Bioanalytical Chemistry 406 (25): 6165–78. https://doi.org/10.1007/s00216-014-8066-3.
Kern, Susanne, et al. “Detection of Potentially Skin Sensitizing Hydroperoxides of Linalool in Fragranced Products.” Analytical and Bioanalytical Chemistry, vol. 406, no. 25, Oct. 2014, pp. 6165–78, https://doi.org/10.1007/s00216-014-8066-3.


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