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Title: Immunomodulation by zearalenone in carp (Cyprinus carpio L.)
Authors : Pietsch-Schmied, Constanze
Junge, Ranka
Burkhardt-Holm, Patricia
Published in : BioMed Research International
Volume(Issue) : 2015
Issue : 420702
Publisher / Ed. Institution : Hindawi
Issue Date: 2015
License (according to publishing contract) : CC BY 3.0: Namensnennung 3.0 Unported
Type of review: Peer review (Publication)
Language : English
Subjects : Mycotoxin; Immune system; Carp; Aquaculture
Subject (DDC) : 572: Biochemistry
Abstract: The mycotoxin zearalenone (ZEN) is a frequent contaminant of animal feeds, but its effects on fish have not yet been investigated extensively. In order to fill this gap a feeding trial with juvenile carp was conducted. Three groups of fish were fed feeds contaminated with ZEN at three concentrations (low: 332 mg kg-1, medium: 621 mg kg-1, and high: 797 mg kg-1 feed) for four weeks. Possible reversible effects of ZEN were evaluated by feeding an additional group with the ZEN-contaminated feeds for four weeks, followed by the uncontaminated diet for two weeks. Immune function of isolated leukocytes from head kidney and trunk kidney was assessed using the assessment of NO production, the respiratory burst assay, the chemiluminescence assay and the measurement of arginase activities. These investigations frequently revealed increased immune responses after exposure of fish to low ZEN concentrations and reduced immune responses after exposure to high mycotoxin concentrations. Moreover, the feeding of the uncontaminated diet for further two weeks did not improve the immune responses in most cases. These results indicate that cellular immune functions in ZEN-contaminated carp are profoundly influenced which may be relevant for fish health in aquaculture.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Natural Resource Sciences (IUNR)
Publication type: Article in scientific Journal
DOI : 10.1155/2015/420702
ISSN: 2314-6133
Appears in Collections:Publikationen Life Sciences und Facility Management

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