Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-1600
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dc.contributor.authorPietsch-Schmied, Constanze-
dc.contributor.authorJunge, Ranka-
dc.contributor.authorBurkhardt-Holm, Patricia-
dc.date.accessioned2018-01-31T13:05:31Z-
dc.date.available2018-01-31T13:05:31Z-
dc.date.issued2015-
dc.identifier.issn2314-6133de_CH
dc.identifier.issn2314-6141de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2361-
dc.description.abstractThe mycotoxin zearalenone (ZEN) is a frequent contaminant of animal feeds, but its effects on fish have not yet been investigated extensively. In order to fill this gap a feeding trial with juvenile carp was conducted. Three groups of fish were fed feeds contaminated with ZEN at three concentrations (low: 332 mg kg-1, medium: 621 mg kg-1, and high: 797 mg kg-1 feed) for four weeks. Possible reversible effects of ZEN were evaluated by feeding an additional group with the ZEN-contaminated feeds for four weeks, followed by the uncontaminated diet for two weeks. Immune function of isolated leukocytes from head kidney and trunk kidney was assessed using the assessment of NO production, the respiratory burst assay, the chemiluminescence assay and the measurement of arginase activities. These investigations frequently revealed increased immune responses after exposure of fish to low ZEN concentrations and reduced immune responses after exposure to high mycotoxin concentrations. Moreover, the feeding of the uncontaminated diet for further two weeks did not improve the immune responses in most cases. These results indicate that cellular immune functions in ZEN-contaminated carp are profoundly influenced which may be relevant for fish health in aquaculture.de_CH
dc.language.isoende_CH
dc.publisherHindawide_CH
dc.relation.ispartofBioMed Research Internationalde_CH
dc.rightshttps://creativecommons.org/licenses/by/3.0/de_CH
dc.subjectMycotoxinde_CH
dc.subjectImmune systemde_CH
dc.subjectCarpde_CH
dc.subjectAquaculturede_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleImmunomodulation by zearalenone in carp (Cyprinus carpio L.)de_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Umwelt und Natürliche Ressourcen (IUNR)de_CH
dc.identifier.doi10.21256/zhaw-1600-
dc.identifier.doi10.1155/2015/420702de_CH
zhaw.funding.euNode_CH
zhaw.issue420702de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume2015de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedAquakultur-Systemede_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Pietsch-Schmied, C., Junge, R., & Burkhardt-Holm, P. (2015). Immunomodulation by zearalenone in carp (Cyprinus carpio L.). BioMed Research International, 2015(420702). https://doi.org/10.21256/zhaw-1600
Pietsch-Schmied, C., Junge, R. and Burkhardt-Holm, P. (2015) ‘Immunomodulation by zearalenone in carp (Cyprinus carpio L.)’, BioMed Research International, 2015(420702). Available at: https://doi.org/10.21256/zhaw-1600.
C. Pietsch-Schmied, R. Junge, and P. Burkhardt-Holm, “Immunomodulation by zearalenone in carp (Cyprinus carpio L.),” BioMed Research International, vol. 2015, no. 420702, 2015, doi: 10.21256/zhaw-1600.
PIETSCH-SCHMIED, Constanze, Ranka JUNGE und Patricia BURKHARDT-HOLM, 2015. Immunomodulation by zearalenone in carp (Cyprinus carpio L.). BioMed Research International. 2015. Bd. 2015, Nr. 420702. DOI 10.21256/zhaw-1600
Pietsch-Schmied, Constanze, Ranka Junge, and Patricia Burkhardt-Holm. 2015. “Immunomodulation by Zearalenone in Carp (Cyprinus Carpio L.).” BioMed Research International 2015 (420702). https://doi.org/10.21256/zhaw-1600.
Pietsch-Schmied, Constanze, et al. “Immunomodulation by Zearalenone in Carp (Cyprinus Carpio L.).” BioMed Research International, vol. 2015, no. 420702, 2015, https://doi.org/10.21256/zhaw-1600.


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