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|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samples|
Luca, Simon Vlad
|Published in:||Phytochemical Analysis|
|Publisher / Ed. Institution:||Wiley|
|Subjects:||Symphytum officinale L; High-resolution mass spectrometry; Phenolic marker; Pyrrolizidine alkaloid; Rosmarinic acid|
|Subject (DDC):||572: Biochemistry |
615: Pharmacology and therapeutics
|Abstract:||Introduction: Symphytum officinale L. (comfrey, Boraginaceae) is a cultivated or spontaneously growing medicinal plant that is traditionally used for the treatment of bone fractures, hematomas, muscle pains and joint pains. A wide range of topical preparations and dried roots for ex tempore applications are marketed in European drug stores or pharmacies. Objective: The aim of this study was to perform the qualitative and quantitative analysis of pyrrolizidine alkaloids (PAs) and phenolic compounds in the hydroethanolic extracts of 16 commercial comfrey root batches purchased from 12 different European countries. Methods: Liquid chromatography hyphenated with high-resolution tandem mass spectrometry (LC-HRMS/MS) was used for the profiling of PAs and phenolic compounds, whereas LC-MS/MS and liquid chromatography with diode array detection (LC-DAD) were used for their quantification. Results: 20 PAs (i.e. intermedine, lycopsamine, acetylintermedine, acetyllycopsamine, symphytine, symphytine-N-oxide), 17 phenolic compounds (i.e. caffeic and rosmarinic acids, rabdosiin, globoidnan A, globoidnan B) and 9 nonphenolic compounds (sugars, organic and fatty acids) were fully or partly annotated in the analysed samples. In addition, the quantitative analyses revealed that globoidnan B, rabdosiin and globoidnan A are new phenolic markers that can be used together with rosmarinic acid and PAs for the quality control of commercial comfrey root batches. Conclusions: This study brings new insights into the phytochemical complexity of S. officinale, revealing not only numerous toxic PAs, but also a significant number of valuable phenolic compounds that could contribute to the bioactivities of comfreybased preparations|
|Fulltext version:||Published version|
|License (according to publishing contract):||CC BY 4.0: Attribution 4.0 International|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Appears in collections:||Publikationen Life Sciences und Facility Management|
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Trifan, A., Wolfram, E., Esslinger, N., Grubelnik, A., Skalicka‐Woźniak, K., Minceva, M., & Luca, S. V. (2020). Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samples. Phytochemical Analysis, 32(4), 482–494. https://doi.org/10.1002/pca.2996
Trifan, A. et al. (2020) ‘Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samples’, Phytochemical Analysis, 32(4), pp. 482–494. Available at: https://doi.org/10.1002/pca.2996.
A. Trifan et al., “Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samples,” Phytochemical Analysis, vol. 32, no. 4, pp. 482–494, 2020, doi: 10.1002/pca.2996.
Trifan, Adriana, et al. “Globoidnan A, Rabdosiin and Globoidnan B as New Phenolic Markers in European‐Sourced Comfrey (Symphytum Officinale L.) Root Samples.” Phytochemical Analysis, vol. 32, no. 4, 2020, pp. 482–94, https://doi.org/10.1002/pca.2996.
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