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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-20652
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dc.contributor.authorTrifan, Adriana-
dc.contributor.authorWolfram, Evelyn-
dc.contributor.authorEsslinger, Nils-
dc.contributor.authorGrubelnik, Andreas-
dc.contributor.authorSkalicka‐Woźniak, Krystyna-
dc.contributor.authorMinceva, Mirjana-
dc.contributor.authorLuca, Simon Vlad-
dc.date.accessioned2020-10-21T14:03:35Z-
dc.date.available2020-10-21T14:03:35Z-
dc.date.issued2020-
dc.identifier.issn0958-0344de_CH
dc.identifier.issn1099-1565de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/20652-
dc.description.abstractIntroduction: Symphytum officinale L. (comfrey, Boraginaceae) is a cultivated or spontaneously growing medicinal plant that is traditionally used for the treatment of bone fractures, hematomas, muscle pains and joint pains. A wide range of topical preparations and dried roots for ex tempore applications are marketed in European drug stores or pharmacies. Objective: The aim of this study was to perform the qualitative and quantitative analysis of pyrrolizidine alkaloids (PAs) and phenolic compounds in the hydroethanolic extracts of 16 commercial comfrey root batches purchased from 12 different European countries. Methods: Liquid chromatography hyphenated with high-resolution tandem mass spectrometry (LC-HRMS/MS) was used for the profiling of PAs and phenolic compounds, whereas LC-MS/MS and liquid chromatography with diode array detection (LC-DAD) were used for their quantification. Results: 20 PAs (i.e. intermedine, lycopsamine, acetylintermedine, acetyllycopsamine, symphytine, symphytine-N-oxide), 17 phenolic compounds (i.e. caffeic and rosmarinic acids, rabdosiin, globoidnan A, globoidnan B) and 9 nonphenolic compounds (sugars, organic and fatty acids) were fully or partly annotated in the analysed samples. In addition, the quantitative analyses revealed that globoidnan B, rabdosiin and globoidnan A are new phenolic markers that can be used together with rosmarinic acid and PAs for the quality control of commercial comfrey root batches. Conclusions: This study brings new insights into the phytochemical complexity of S. officinale, revealing not only numerous toxic PAs, but also a significant number of valuable phenolic compounds that could contribute to the bioactivities of comfreybased preparationsde_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofPhytochemical Analysisde_CH
dc.rightshttps://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectSymphytum officinale Lde_CH
dc.subjectHigh-resolution mass spectrometryde_CH
dc.subjectPhenolic markerde_CH
dc.subjectPyrrolizidine alkaloidde_CH
dc.subjectRosmarinic acidde_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleGloboidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samplesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1002/pca.2996de_CH
dc.identifier.doi10.21256/zhaw-20652-
dc.identifier.pmid33015885de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end494de_CH
zhaw.pages.start482de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume32de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPhytopharmaziede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Trifan, A., Wolfram, E., Esslinger, N., Grubelnik, A., Skalicka‐Woźniak, K., Minceva, M., & Luca, S. V. (2020). Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samples. Phytochemical Analysis, 32(4), 482–494. https://doi.org/10.1002/pca.2996
Trifan, A. et al. (2020) ‘Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samples’, Phytochemical Analysis, 32(4), pp. 482–494. Available at: https://doi.org/10.1002/pca.2996.
A. Trifan et al., “Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samples,” Phytochemical Analysis, vol. 32, no. 4, pp. 482–494, 2020, doi: 10.1002/pca.2996.
TRIFAN, Adriana, Evelyn WOLFRAM, Nils ESSLINGER, Andreas GRUBELNIK, Krystyna SKALICKA‐WOŹNIAK, Mirjana MINCEVA und Simon Vlad LUCA, 2020. Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European‐sourced comfrey (Symphytum officinale L.) root samples. Phytochemical Analysis. 2020. Bd. 32, Nr. 4, S. 482–494. DOI 10.1002/pca.2996
Trifan, Adriana, Evelyn Wolfram, Nils Esslinger, Andreas Grubelnik, Krystyna Skalicka‐Woźniak, Mirjana Minceva, and Simon Vlad Luca. 2020. “Globoidnan A, Rabdosiin and Globoidnan B as New Phenolic Markers in European‐Sourced Comfrey (Symphytum Officinale L.) Root Samples.” Phytochemical Analysis 32 (4): 482–94. https://doi.org/10.1002/pca.2996.
Trifan, Adriana, et al. “Globoidnan A, Rabdosiin and Globoidnan B as New Phenolic Markers in European‐Sourced Comfrey (Symphytum Officinale L.) Root Samples.” Phytochemical Analysis, vol. 32, no. 4, 2020, pp. 482–94, https://doi.org/10.1002/pca.2996.


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