Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3363
Title: Spectroscopic analysis of melatonin in the terahertz frequency range
Authors : Puc, Uroš
Abina, Andreja
Jeglič, Anton
Zidanšek, Aleksander
Kašalynas, Irmantas
Venckevičius, Rimvydas
Valušis, Gintaras
Published in : Sensors
Volume(Issue) : 18
Issue : 12
Pages : 4098
Publisher / Ed. Institution : MDPI
Issue Date: 2018
License (according to publishing contract) : CC BY 4.0: Attribution 4.0 International
Type of review: Peer review (Publication)
Language : English
Subjects : Fourier transform infrared spectroscopy; Active pharmaceutical ingredient; Hormon; Pharmaceutical industry; Terahertz imaging; Terahertz spectroscopy; Humans; Melatonin
Subject (DDC) : 530: Physics
Abstract: There is a need for fast and reliable quality and authenticity control tools of pharmaceutical ingredients. Among others, hormone containing drugs and foods are subject to scrutiny. In this study, terahertz (THz) spectroscopy and THz imaging are applied for the first time to analyze melatonin and its pharmaceutical product Circadin. Melatonin is a hormone found naturally in the human body, which is responsible for the regulation of sleep-wake cycles. In the THz frequency region between 1.5 THz and 4.5 THz, characteristic melatonin spectral features at 3.21 THz, and a weaker one at 4.20 THz, are observed allowing for a quantitative analysis within the final products. Spectroscopic THz imaging of different concentrations of Circadin and melatonin as an active pharmaceutical ingredient in prepared pellets is also performed, which permits spatial recognition of these different substances. These results indicate that THz spectroscopy and imaging can be an indispensable tool, complementing Raman and Fourier transform infrared spectroscopies, in order to provide quality control of dietary supplements and other pharmaceutical products.
Departement: School of Engineering
Organisational Unit: Institute of Computational Physics (ICP)
Publication type: Article in scientific Journal
DOI : 10.21256/zhaw-3363
10.3390/s18124098
ISSN: 1424-8220
1424-8239
URI: https://digitalcollection.zhaw.ch/handle/11475/15673
Appears in Collections:Publikationen School of Engineering

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