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https://doi.org/10.21256/zhaw-3363| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Spectroscopic analysis of melatonin in the terahertz frequency range |
| Autor/-in: | Puc, Uroš Abina, Andreja Jeglič, Anton Zidanšek, Aleksander Kašalynas, Irmantas Venckevičius, Rimvydas Valušis, Gintaras |
| DOI: | 10.21256/zhaw-3363 10.3390/s18124098 |
| Erschienen in: | Sensors |
| Band(Heft): | 18 |
| Heft: | 12 |
| Seite(n): | 4098 |
| Erscheinungsdatum: | 2018 |
| Verlag / Hrsg. Institution: | MDPI |
| ISSN: | 1424-8220 1424-8239 |
| Sprache: | Englisch |
| Schlagwörter: | Fourier transform infrared spectroscopy; Active pharmaceutical ingredient; Hormon; Pharmaceutical industry; Terahertz imaging; Terahertz spectroscopy; Humans; Melatonin |
| Fachgebiet (DDC): | 530: Physik |
| Zusammenfassung: | There is a need for fast and reliable quality and authenticity control tools of pharmaceutical ingredients. Among others, hormone containing drugs and foods are subject to scrutiny. In this study, terahertz (THz) spectroscopy and THz imaging are applied for the first time to analyze melatonin and its pharmaceutical product Circadin. Melatonin is a hormone found naturally in the human body, which is responsible for the regulation of sleep-wake cycles. In the THz frequency region between 1.5 THz and 4.5 THz, characteristic melatonin spectral features at 3.21 THz, and a weaker one at 4.20 THz, are observed allowing for a quantitative analysis within the final products. Spectroscopic THz imaging of different concentrations of Circadin and melatonin as an active pharmaceutical ingredient in prepared pellets is also performed, which permits spatial recognition of these different substances. These results indicate that THz spectroscopy and imaging can be an indispensable tool, complementing Raman and Fourier transform infrared spectroscopies, in order to provide quality control of dietary supplements and other pharmaceutical products. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/15673 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | School of Engineering |
| Organisationseinheit: | Institute of Computational Physics (ICP) |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| sensors-18-04098.pdf | 2.55 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Puc, U., Abina, A., Jeglič, A., Zidanšek, A., Kašalynas, I., Venckevičius, R., & Valušis, G. (2018). Spectroscopic analysis of melatonin in the terahertz frequency range. Sensors, 18(12), 4098. https://doi.org/10.21256/zhaw-3363
Puc, U. et al. (2018) ‘Spectroscopic analysis of melatonin in the terahertz frequency range’, Sensors, 18(12), p. 4098. Available at: https://doi.org/10.21256/zhaw-3363.
U. Puc et al., “Spectroscopic analysis of melatonin in the terahertz frequency range,” Sensors, vol. 18, no. 12, p. 4098, 2018, doi: 10.21256/zhaw-3363.
PUC, Uroš, Andreja ABINA, Anton JEGLIČ, Aleksander ZIDANŠEK, Irmantas KAŠALYNAS, Rimvydas VENCKEVIČIUS und Gintaras VALUŠIS, 2018. Spectroscopic analysis of melatonin in the terahertz frequency range. Sensors. 2018. Bd. 18, Nr. 12, S. 4098. DOI 10.21256/zhaw-3363
Puc, Uroš, Andreja Abina, Anton Jeglič, Aleksander Zidanšek, Irmantas Kašalynas, Rimvydas Venckevičius, and Gintaras Valušis. 2018. “Spectroscopic Analysis of Melatonin in the Terahertz Frequency Range.” Sensors 18 (12): 4098. https://doi.org/10.21256/zhaw-3363.
Puc, Uroš, et al. “Spectroscopic Analysis of Melatonin in the Terahertz Frequency Range.” Sensors, vol. 18, no. 12, 2018, p. 4098, https://doi.org/10.21256/zhaw-3363.
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