Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPuc, Uroš-
dc.contributor.authorAbina, Andreja-
dc.contributor.authorJeglič, Anton-
dc.contributor.authorZidanšek, Aleksander-
dc.contributor.authorKašalynas, Irmantas-
dc.contributor.authorVenckevičius, Rimvydas-
dc.contributor.authorValušis, Gintaras-
dc.description.abstractThere is a need for fast and reliable quality and authenticity control tools of pharmaceutical ingredients. Among others, hormone containing drugs and foods are subject to scrutiny. In this study, terahertz (THz) spectroscopy and THz imaging are applied for the first time to analyze melatonin and its pharmaceutical product Circadin. Melatonin is a hormone found naturally in the human body, which is responsible for the regulation of sleep-wake cycles. In the THz frequency region between 1.5 THz and 4.5 THz, characteristic melatonin spectral features at 3.21 THz, and a weaker one at 4.20 THz, are observed allowing for a quantitative analysis within the final products. Spectroscopic THz imaging of different concentrations of Circadin and melatonin as an active pharmaceutical ingredient in prepared pellets is also performed, which permits spatial recognition of these different substances. These results indicate that THz spectroscopy and imaging can be an indispensable tool, complementing Raman and Fourier transform infrared spectroscopies, in order to provide quality control of dietary supplements and other pharmaceutical products.de_CH
dc.subjectFourier transform infrared spectroscopyde_CH
dc.subjectActive pharmaceutical ingredientde_CH
dc.subjectPharmaceutical industryde_CH
dc.subjectTerahertz imagingde_CH
dc.subjectTerahertz spectroscopyde_CH
dc.subject.ddc530: Physikde_CH
dc.titleSpectroscopic analysis of melatonin in the terahertz frequency rangede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitute of Computational Physics (ICP)de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in collections:Publikationen School of Engineering

Files in This Item:
File Description SizeFormat 
sensors-18-04098.pdf2.55 MBAdobe PDFThumbnail
Show simple item record
Puc, U., Abina, A., Jeglič, A., Zidanšek, A., Kašalynas, I., Venckevičius, R., & Valušis, G. (2018). Spectroscopic analysis of melatonin in the terahertz frequency range. Sensors, 18(12), 4098.
Puc, U. et al. (2018) ‘Spectroscopic analysis of melatonin in the terahertz frequency range’, Sensors, 18(12), p. 4098. Available at:
U. Puc et al., “Spectroscopic analysis of melatonin in the terahertz frequency range,” Sensors, vol. 18, no. 12, p. 4098, 2018, doi: 10.21256/zhaw-3363.
PUC, Uroš, Andreja ABINA, Anton JEGLIČ, Aleksander ZIDANŠEK, Irmantas KAŠALYNAS, Rimvydas VENCKEVIČIUS und Gintaras VALUŠIS, 2018. Spectroscopic analysis of melatonin in the terahertz frequency range. Sensors. 2018. Bd. 18, Nr. 12, S. 4098. DOI 10.21256/zhaw-3363
Puc, Uroš, Andreja Abina, Anton Jeglič, Aleksander Zidanšek, Irmantas Kašalynas, Rimvydas Venckevičius, and Gintaras Valušis. 2018. “Spectroscopic Analysis of Melatonin in the Terahertz Frequency Range.” Sensors 18 (12): 4098.
Puc, Uroš, et al. “Spectroscopic Analysis of Melatonin in the Terahertz Frequency Range.” Sensors, vol. 18, no. 12, 2018, p. 4098,

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.