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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3363
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dc.contributor.authorPuc, Uroš-
dc.contributor.authorAbina, Andreja-
dc.contributor.authorJeglič, Anton-
dc.contributor.authorZidanšek, Aleksander-
dc.contributor.authorKašalynas, Irmantas-
dc.contributor.authorVenckevičius, Rimvydas-
dc.contributor.authorValušis, Gintaras-
dc.date.accessioned2019-02-26T17:09:22Z-
dc.date.available2019-02-26T17:09:22Z-
dc.date.issued2018-
dc.identifier.issn1424-8220de_CH
dc.identifier.issn1424-8239de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/15673-
dc.description.abstractThere is a need for fast and reliable quality and authenticity control tools of pharmaceutical ingredients. Among others, hormone containing drugs and foods are subject to scrutiny. In this study, terahertz (THz) spectroscopy and THz imaging are applied for the first time to analyze melatonin and its pharmaceutical product Circadin. Melatonin is a hormone found naturally in the human body, which is responsible for the regulation of sleep-wake cycles. In the THz frequency region between 1.5 THz and 4.5 THz, characteristic melatonin spectral features at 3.21 THz, and a weaker one at 4.20 THz, are observed allowing for a quantitative analysis within the final products. Spectroscopic THz imaging of different concentrations of Circadin and melatonin as an active pharmaceutical ingredient in prepared pellets is also performed, which permits spatial recognition of these different substances. These results indicate that THz spectroscopy and imaging can be an indispensable tool, complementing Raman and Fourier transform infrared spectroscopies, in order to provide quality control of dietary supplements and other pharmaceutical products.de_CH
dc.language.isoende_CH
dc.publisherMDPIde_CH
dc.relation.ispartofSensorsde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectFourier transform infrared spectroscopyde_CH
dc.subjectActive pharmaceutical ingredientde_CH
dc.subjectHormonde_CH
dc.subjectPharmaceutical industryde_CH
dc.subjectTerahertz imagingde_CH
dc.subjectTerahertz spectroscopyde_CH
dc.subjectHumansde_CH
dc.subjectMelatoninde_CH
dc.subject.ddc530: Physikde_CH
dc.titleSpectroscopic analysis of melatonin in the terahertz frequency rangede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitute of Computational Physics (ICP)de_CH
dc.identifier.doi10.21256/zhaw-3363-
dc.identifier.doi10.3390/s18124098de_CH
dc.identifier.pmid30477140de_CH
zhaw.funding.euNode_CH
zhaw.issue12de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start4098de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume18de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Puc, U., Abina, A., Jeglič, A., Zidanšek, A., Kašalynas, I., Venckevičius, R., & Valušis, G. (2018). Spectroscopic analysis of melatonin in the terahertz frequency range. Sensors, 18(12), 4098. https://doi.org/10.21256/zhaw-3363
Puc, U. et al. (2018) ‘Spectroscopic analysis of melatonin in the terahertz frequency range’, Sensors, 18(12), p. 4098. Available at: https://doi.org/10.21256/zhaw-3363.
U. Puc et al., “Spectroscopic analysis of melatonin in the terahertz frequency range,” Sensors, vol. 18, no. 12, p. 4098, 2018, doi: 10.21256/zhaw-3363.
PUC, Uroš, Andreja ABINA, Anton JEGLIČ, Aleksander ZIDANŠEK, Irmantas KAŠALYNAS, Rimvydas VENCKEVIČIUS und Gintaras VALUŠIS, 2018. Spectroscopic analysis of melatonin in the terahertz frequency range. Sensors. 2018. Bd. 18, Nr. 12, S. 4098. DOI 10.21256/zhaw-3363
Puc, Uroš, Andreja Abina, Anton Jeglič, Aleksander Zidanšek, Irmantas Kašalynas, Rimvydas Venckevičius, and Gintaras Valušis. 2018. “Spectroscopic Analysis of Melatonin in the Terahertz Frequency Range.” Sensors 18 (12): 4098. https://doi.org/10.21256/zhaw-3363.
Puc, Uroš, et al. “Spectroscopic Analysis of Melatonin in the Terahertz Frequency Range.” Sensors, vol. 18, no. 12, 2018, p. 4098, https://doi.org/10.21256/zhaw-3363.


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