| Title: | High-temperature Diels–Alder reactions : transfer from batch to continuous mode |
| Authors : | Abele, Stefan Höck, Stefan Schmidt, Gunther Funel, Jacques-Alexis Marti, Roger |
| Published in : | Organic process research & development |
| Volume(Issue) : | 16 |
| Issue : | 5 |
| Pages : | 1114 |
| Pages to: | 1120 |
| Publisher / Ed. Institution : | American Chemical Society |
| Issue Date: | 2012 |
| License (according to publishing contract) : | Licence according to publishing contract |
| Type of review: | Peer review (Publication) |
| Language : | English |
| Subjects : | Diels-Alder Reaction; Microreactor; Flow Chemistry |
| Subject (DDC) : | 540: Chemistry |
| Abstract: | The transfer of a Diels–Alder reaction of (cyclohexa-1,5-dien-1-yloxy)trimethylsilane with α-acetoxyacrylonitrile and acrylonitrile, respectively, from batch to continuous mode is presented, using standard and widely available laboratory equipment. A standard microwave-based system was used as probe for the transfer to flow reactors. Temperature and residence time have been optimized in small coiled-tube reactors and confirmed with two production runs in a flow reactor. The inherent increase in safety caused by the small volumes at high temperatures and the achieved productivity (approximately 100 g/h using acrylonitrile) are offering advantages over the batch mode which suffers from thermokinetic limitations for scale-up. |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Publication type: | Article in scientific Journal |
| DOI : | 10.1021/op200320w |
| ISSN: | 1083-6160 1520-586X |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/11996 |
| Appears in Collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.