| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | High-temperature Diels–Alder reactions : transfer from batch to continuous mode |
| Authors: | Abele, Stefan Höck, Stefan Schmidt, Gunther Funel, Jacques-Alexis Marti, Roger |
| DOI: | 10.1021/op200320w |
| Published in: | Organic Process Research & Development |
| Volume(Issue): | 16 |
| Issue: | 5 |
| Pages: | 1114 |
| Pages to: | 1120 |
| Issue Date: | 2012 |
| Publisher / Ed. Institution: | American Chemical Society |
| ISSN: | 1083-6160 1520-586X |
| Language: | English |
| Subjects: | Diels-Alder Reaction; Microreactor; Flow Chemistry |
| Subject (DDC): | 540: Chemistry |
| Abstract: | The transfer of a Diels–Alder reaction of (cyclohexa-1,5-dien-1-yloxy)trimethylsilane with α-acetoxyacrylonitrile and acrylonitrile, respectively, from batch to continuous mode is presented, using standard and widely available laboratory equipment. A standard microwave-based system was used as probe for the transfer to flow reactors. Temperature and residence time have been optimized in small coiled-tube reactors and confirmed with two production runs in a flow reactor. The inherent increase in safety caused by the small volumes at high temperatures and the achieved productivity (approximately 100 g/h using acrylonitrile) are offering advantages over the batch mode which suffers from thermokinetic limitations for scale-up. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/11996 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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