Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: High-temperature Diels–Alder reactions : transfer from batch to continuous mode
Authors: Abele, Stefan
Höck, Stefan
Schmidt, Gunther
Funel, Jacques-Alexis
Marti, Roger
DOI: 10.1021/op200320w
Published in: Organic Process Research & Development
Volume(Issue): 16
Issue: 5
Pages: 1114
Pages to: 1120
Issue Date: 2012
Publisher / Ed. Institution: American Chemical Society
ISSN: 1083-6160
Language: English
Subjects: Diels-Alder Reaction; Microreactor; Flow Chemistry
Subject (DDC): 540: Chemistry
Abstract: The transfer of a Diels–Alder reaction of (cyclohexa-1,5-dien-1-yloxy)trimethylsilane with α-acetoxyacrylonitrile and acrylonitrile, respectively, from batch to continuous mode is presented, using standard and widely available laboratory equipment. A standard microwave-based system was used as probe for the transfer to flow reactors. Temperature and residence time have been optimized in small coiled-tube reactors and confirmed with two production runs in a flow reactor. The inherent increase in safety caused by the small volumes at high temperatures and the achieved productivity (approximately 100 g/h using acrylonitrile) are offering advantages over the batch mode which suffers from thermokinetic limitations for scale-up.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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