Title: High-temperature Diels–Alder reactions : transfer from batch to continuous mode
Authors : Abele, Stefan
Höck, Stefan
Schmidt, Gunther
Funel, Jacques-Alexis
Marti, Roger
Published in : Organic process research & development
Volume(Issue) : 16
Issue : 5
Pages : 1114
Pages to: 1120
Publisher / Ed. Institution : American Chemical Society
Issue Date: 2012
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Diels-Alder Reaction; Microreactor; Flow Chemistry
Subject (DDC) : 540: Chemistry
Abstract: The transfer of a Diels–Alder reaction of (cyclohexa-1,5-dien-1-yloxy)trimethylsilane with α-acetoxyacrylonitrile and acrylonitrile, respectively, from batch to continuous mode is presented, using standard and widely available laboratory equipment. A standard microwave-based system was used as probe for the transfer to flow reactors. Temperature and residence time have been optimized in small coiled-tube reactors and confirmed with two production runs in a flow reactor. The inherent increase in safety caused by the small volumes at high temperatures and the achieved productivity (approximately 100 g/h using acrylonitrile) are offering advantages over the batch mode which suffers from thermokinetic limitations for scale-up.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1021/op200320w
ISSN: 1083-6160
1520-586X
URI: https://digitalcollection.zhaw.ch/handle/11475/11996
Appears in Collections:Publikationen Life Sciences und Facility Management

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