High-temperature Diels–Alder reactions : transfer from batch to continuous mode

Abele, Stefan; Höck, Stefan; Schmidt, Gunther; Funel, Jacques-Alexis; Marti, Roger

doi:10.1021/op200320w

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	High-temperature Diels–Alder reactions : transfer from batch to continuous mode
Authors:	Abele, Stefan Höck, Stefan Schmidt, Gunther Funel, Jacques-Alexis Marti, Roger
DOI:	10.1021/op200320w
Published in:	Organic Process Research & Development
Volume(Issue):	16
Issue:	5
Page(s):	1114
Pages to:	1120
Issue Date:	2012
Publisher / Ed. Institution:	American Chemical Society
ISSN:	1083-6160 1520-586X
Language:	English
Subjects:	Diels-Alder Reaction; Microreactor; Flow Chemistry
Subject (DDC):	540: Chemistry
Abstract:	The transfer of a Diels–Alder reaction of (cyclohexa-1,5-dien-1-yloxy)trimethylsilane with α-acetoxyacrylonitrile and acrylonitrile, respectively, from batch to continuous mode is presented, using standard and widely available laboratory equipment. A standard microwave-based system was used as probe for the transfer to flow reactors. Temperature and residence time have been optimized in small coiled-tube reactors and confirmed with two production runs in a flow reactor. The inherent increase in safety caused by the small volumes at high temperatures and the achieved productivity (approximately 100 g/h using acrylonitrile) are offering advantages over the batch mode which suffers from thermokinetic limitations for scale-up.
URI:	https://digitalcollection.zhaw.ch/handle/11475/11996
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Abele, S., Höck, S., Schmidt, G., Funel, J.-A., & Marti, R. (2012). High-temperature Diels–Alder reactions : transfer from batch to continuous mode. Organic Process Research & Development, 16(5), 1114–1120. https://doi.org/10.1021/op200320w

Abele, S. et al. (2012) ‘High-temperature Diels–Alder reactions : transfer from batch to continuous mode’, Organic Process Research & Development, 16(5), pp. 1114–1120. Available at: https://doi.org/10.1021/op200320w.

S. Abele, S. Höck, G. Schmidt, J.-A. Funel, and R. Marti, “High-temperature Diels–Alder reactions : transfer from batch to continuous mode,” Organic Process Research & Development, vol. 16, no. 5, pp. 1114–1120, 2012, doi: 10.1021/op200320w.

ABELE, Stefan, Stefan HÖCK, Gunther SCHMIDT, Jacques-Alexis FUNEL und Roger MARTI, 2012. High-temperature Diels–Alder reactions : transfer from batch to continuous mode. Organic Process Research & Development. 2012. Bd. 16, Nr. 5, S. 1114–1120. DOI 10.1021/op200320w

Abele, Stefan, Stefan Höck, Gunther Schmidt, Jacques-Alexis Funel, and Roger Marti. 2012. “High-Temperature Diels–Alder Reactions : Transfer from Batch to Continuous Mode.” Organic Process Research & Development 16 (5): 1114–20. https://doi.org/10.1021/op200320w.

Abele, Stefan, et al. “High-Temperature Diels–Alder Reactions : Transfer from Batch to Continuous Mode.” Organic Process Research & Development, vol. 16, no. 5, 2012, pp. 1114–20, https://doi.org/10.1021/op200320w.