Publication type: | Article in scientific journal |
Type of review: | Peer review (publication) |
Title: | High-temperature Diels–Alder reactions : transfer from batch to continuous mode |
Authors: | Abele, Stefan Höck, Stefan Schmidt, Gunther Funel, Jacques-Alexis Marti, Roger |
DOI: | 10.1021/op200320w |
Published in: | Organic Process Research & Development |
Volume(Issue): | 16 |
Issue: | 5 |
Page(s): | 1114 |
Pages to: | 1120 |
Issue Date: | 2012 |
Publisher / Ed. Institution: | American Chemical Society |
ISSN: | 1083-6160 1520-586X |
Language: | English |
Subjects: | Diels-Alder Reaction; Microreactor; Flow Chemistry |
Subject (DDC): | 540: Chemistry |
Abstract: | The transfer of a Diels–Alder reaction of (cyclohexa-1,5-dien-1-yloxy)trimethylsilane with α-acetoxyacrylonitrile and acrylonitrile, respectively, from batch to continuous mode is presented, using standard and widely available laboratory equipment. A standard microwave-based system was used as probe for the transfer to flow reactors. Temperature and residence time have been optimized in small coiled-tube reactors and confirmed with two production runs in a flow reactor. The inherent increase in safety caused by the small volumes at high temperatures and the achieved productivity (approximately 100 g/h using acrylonitrile) are offering advantages over the batch mode which suffers from thermokinetic limitations for scale-up. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/11996 |
Fulltext version: | Published version |
License (according to publishing contract): | Licence according to publishing contract |
Departement: | Life Sciences and Facility Management |
Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
Appears in collections: | Publikationen Life Sciences und Facility Management |
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Abele, S., Höck, S., Schmidt, G., Funel, J.-A., & Marti, R. (2012). High-temperature Diels–Alder reactions : transfer from batch to continuous mode. Organic Process Research & Development, 16(5), 1114–1120. https://doi.org/10.1021/op200320w
Abele, S. et al. (2012) ‘High-temperature Diels–Alder reactions : transfer from batch to continuous mode’, Organic Process Research & Development, 16(5), pp. 1114–1120. Available at: https://doi.org/10.1021/op200320w.
S. Abele, S. Höck, G. Schmidt, J.-A. Funel, and R. Marti, “High-temperature Diels–Alder reactions : transfer from batch to continuous mode,” Organic Process Research & Development, vol. 16, no. 5, pp. 1114–1120, 2012, doi: 10.1021/op200320w.
ABELE, Stefan, Stefan HÖCK, Gunther SCHMIDT, Jacques-Alexis FUNEL und Roger MARTI, 2012. High-temperature Diels–Alder reactions : transfer from batch to continuous mode. Organic Process Research & Development. 2012. Bd. 16, Nr. 5, S. 1114–1120. DOI 10.1021/op200320w
Abele, Stefan, Stefan Höck, Gunther Schmidt, Jacques-Alexis Funel, and Roger Marti. 2012. “High-Temperature Diels–Alder Reactions : Transfer from Batch to Continuous Mode.” Organic Process Research & Development 16 (5): 1114–20. https://doi.org/10.1021/op200320w.
Abele, Stefan, et al. “High-Temperature Diels–Alder Reactions : Transfer from Batch to Continuous Mode.” Organic Process Research & Development, vol. 16, no. 5, 2012, pp. 1114–20, https://doi.org/10.1021/op200320w.
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