Title: Endothelial cell elongation under shear stress : a computational model to consolidate observed cell shape changes
Authors : Schilling, Sabine
Morel, Sandrine
Bochaton-Piallat, Marie-Luce
Kwak, Brenda
Hirsch, Sven
Proceedings: 5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE2017
Pages : 850
Pages to: 852
Conference details: 5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017, Pittsburgh United States, 10 - 12 April 2017
Editors of the parent work: Nithiarasu, P
Robertson, A M
Publisher / Ed. Institution : Zeta Computational Resources
Publisher / Ed. Institution: Swansea, United Kingdom
Issue Date: 2017
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Abstract)
Language : English
Subjects : Endothelia; Cell-vertex-model; Wall shear stress
Subject (DDC) : 610: Medicine and health
Abstract: The endothelium, a single layer of cells that lines all blood vessels, is the principal sensor of hemodynamic wall shear stress (WSS). Changes in WSS are associated with diseases as inflammation, atherosclerotic plaque formation or aneurysms. It has long been established that endothelial cells are elongated under physiological blood flow conditions, but become cobblestone in culture under no flow conditions. To quantify this change of cell morphology, we measured the circularity and aspect ratio of porcine aortic endothelial cells cultured in physiological flux (30 dynes/cm2) or static condition. A parsimonious biomechanical cell-vertex model allows us for the first time to explain the observed changes in cell morphology by local changes in the cell boundary tension associated with changes in the architecture of the cytoskeletal network.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Applied Simulation (IAS)
Publication type: Conference Paper
ISBN: 978-0-9562914-4-8
ISSN: 2227-9385
URI: https://digitalcollection.zhaw.ch/handle/11475/8211
Appears in Collections:Publikationen Life Sciences und Facility Management

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