| Publication type: | Conference paper |
| Type of review: | Peer review (abstract) |
| Title: | Endothelial cell elongation under shear stress : a computational model to consolidate observed cell shape changes |
| Authors: | Schilling, Sabine Morel, Sandrine Bochaton-Piallat, Marie-Luce Kwak, Brenda Hirsch, Sven |
| Proceedings: | 5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE2017 |
| Editors of the parent work: | Nithiarasu, P. Robertson, A. M. |
| Page(s): | 850 |
| Pages to: | 852 |
| Conference details: | 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, USA, 10-12 April 2017 |
| Issue Date: | 2017 |
| Publisher / Ed. Institution: | Zeta Computational Resources |
| Publisher / Ed. Institution: | Swansea |
| ISBN: | 978-0-9562914-4-8 |
| ISSN: | 2227-9385 |
| Language: | English |
| Subjects: | Endothelia; Cell-vertex-model; Wall shear stress |
| Subject (DDC): | 610: Medicine and health |
| Abstract: | The endothelium, a single layer of cells that lines all blood vessels, is the principal sensor of hemodynamic wall shear stress (WSS). Changes in WSS are associated with diseases as inflammation, atherosclerotic plaque formation or aneurysms. It has long been established that endothelial cells are elongated under physiological blood flow conditions, but become cobblestone in culture under no flow conditions. To quantify this change of cell morphology, we measured the circularity and aspect ratio of porcine aortic endothelial cells cultured in physiological flux (30 dynes/cm2) or static condition. A parsimonious biomechanical cell-vertex model allows us for the first time to explain the observed changes in cell morphology by local changes in the cell boundary tension associated with changes in the architecture of the cytoskeletal network. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/8211 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Computational Life Sciences (ICLS) |
| Published as part of the ZHAW project: | AneuX |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Schilling, S., Morel, S., Bochaton-Piallat, M.-L., Kwak, B., & Hirsch, S. (2017). Endothelial cell elongation under shear stress : a computational model to consolidate observed cell shape changes [Conference paper]. In P. Nithiarasu & A. M. Robertson (Eds.), 5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE2017 (pp. 850–852). Zeta Computational Resources.
Schilling, S. et al. (2017) ‘Endothelial cell elongation under shear stress : a computational model to consolidate observed cell shape changes’, in P. Nithiarasu and A.M. Robertson (eds) 5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE2017. Swansea: Zeta Computational Resources, pp. 850–852.
S. Schilling, S. Morel, M.-L. Bochaton-Piallat, B. Kwak, and S. Hirsch, “Endothelial cell elongation under shear stress : a computational model to consolidate observed cell shape changes,” in 5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE2017, 2017, pp. 850–852.
SCHILLING, Sabine, Sandrine MOREL, Marie-Luce BOCHATON-PIALLAT, Brenda KWAK und Sven HIRSCH, 2017. Endothelial cell elongation under shear stress : a computational model to consolidate observed cell shape changes. In: P. NITHIARASU und A. M. ROBERTSON (Hrsg.), 5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE2017. Conference paper. Swansea: Zeta Computational Resources. 2017. S. 850–852. ISBN 978-0-9562914-4-8
Schilling, Sabine, Sandrine Morel, Marie-Luce Bochaton-Piallat, Brenda Kwak, and Sven Hirsch. 2017. “Endothelial Cell Elongation under Shear Stress : A Computational Model to Consolidate Observed Cell Shape Changes.” Conference paper. In 5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE2017, edited by P. Nithiarasu and A. M. Robertson, 850–52. Swansea: Zeta Computational Resources.
Schilling, Sabine, et al. “Endothelial Cell Elongation under Shear Stress : A Computational Model to Consolidate Observed Cell Shape Changes.” 5th International Conference on Computational and Mathematical Biomedical Engineering, CMBE2017, edited by P. Nithiarasu and A. M. Robertson, Zeta Computational Resources, 2017, pp. 850–52.
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