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Title: Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach
Authors : Scheidegger, Stephan
Fuchs, Hans Ulrich
Zaugg, Kathrin
Bodis, Stephan
Füchslin, Rudolf Marcel
Published in : Computational and Mathematical Methods in Medicine
Volume(Issue) : 2013
Issue : 587543
Publisher / Ed. Institution : Hindawi
Issue Date: 2013
License (according to publishing contract) : CC BY 3.0: Namensnennung 3.0 Unported
Type of review: Peer review (Publication)
Language : English
Subject (DDC) : 615: Pharmacology and therapeutics
Abstract: In order to overcome the limitations of the linear-quadratic model and include synergistic effects of heat and radiation, a novel radiobiological model is proposed. The model is based on a chain of cell populations which are characterized by the number of radiation induced damages (hits). Cells can shift downward along the chain by collecting hits and upward by a repair process. The repair process is governed by a repair probability which depends upon state variables used for a simplistic description of the impact of heat and radiation upon repair proteins. Based on the parameters used, populations up to 4-5 hits are relevant for the calculation of the survival. The model describes intuitively the mathematical behaviour of apoptotic and nonapoptotic cell death. Linear-quadratic-linear behaviour of the logarithmic cell survival, fractionation, and (with one exception) the dose rate dependencies are described correctly. The model covers the time gap dependence of the synergistic cell killing due to combined application of heat and radiation, but further validation of the proposed approach based on experimental data is needed. However, the model offers a work bench for testing different biological concepts of damage induction, repair, and statistical approaches for calculating the variables of state.
Departement: School of Engineering
Organisational Unit: Institute of Applied Mathematics and Physics (IAMP)
Publication type: Article in scientific Journal
DOI : 10.1155/2013/587543
ISSN: 1748-670X
Appears in Collections:Publikationen School of Engineering

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