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https://doi.org/10.21256/zhaw-1765| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach |
| Autor/-in: | Scheidegger, Stephan Fuchs, Hans Ulrich Zaugg, Kathrin Bodis, Stephan Füchslin, Rudolf Marcel |
| DOI: | 10.21256/zhaw-1765 10.1155/2013/587543 |
| Erschienen in: | Computational and Mathematical Methods in Medicine |
| Band(Heft): | 2013 |
| Heft: | 587543 |
| Erscheinungsdatum: | 2013 |
| Verlag / Hrsg. Institution: | Hindawi |
| ISSN: | 1748-670X 1748-6718 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 615: Pharmakologie und Therapeutik |
| Zusammenfassung: | In order to overcome the limitations of the linear-quadratic model and include synergistic effects of heat and radiation, a novel radiobiological model is proposed. The model is based on a chain of cell populations which are characterized by the number of radiation induced damages (hits). Cells can shift downward along the chain by collecting hits and upward by a repair process. The repair process is governed by a repair probability which depends upon state variables used for a simplistic description of the impact of heat and radiation upon repair proteins. Based on the parameters used, populations up to 4-5 hits are relevant for the calculation of the survival. The model describes intuitively the mathematical behaviour of apoptotic and non-apoptotic cell death. Linear-quadratic-linear behaviour of the logarithmic cell survival, fractionation, and (with one exception) the dose rate dependencies are described correctly. The model covers the time gap dependence of the synergistic cell killing due to combined application of heat and radiation, but further validation of the proposed approach based on experimental data is needed. However, the model offers a work bench for testing different biological concepts of damage induction, repair, and statistical approaches for calculating the variables of state. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/3402 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 3.0: Namensnennung 3.0 Unported |
| Departement: | School of Engineering |
| Organisationseinheit: | Institut für Angewandte Mathematik und Physik (IAMP) |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2013_Scheidegger_Using state variables_Computational and Mathematical Methods in Medicine.pdf | 1.71 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Scheidegger, S., Fuchs, H. U., Zaugg, K., Bodis, S., & Füchslin, R. M. (2013). Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach. Computational and Mathematical Methods in Medicine, 2013(587543). https://doi.org/10.21256/zhaw-1765
Scheidegger, S. et al. (2013) ‘Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach’, Computational and Mathematical Methods in Medicine, 2013(587543). Available at: https://doi.org/10.21256/zhaw-1765.
S. Scheidegger, H. U. Fuchs, K. Zaugg, S. Bodis, and R. M. Füchslin, “Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach,” Computational and Mathematical Methods in Medicine, vol. 2013, no. 587543, 2013, doi: 10.21256/zhaw-1765.
SCHEIDEGGER, Stephan, Hans Ulrich FUCHS, Kathrin ZAUGG, Stephan BODIS und Rudolf Marcel FÜCHSLIN, 2013. Using state variables to model the response of tumour cells to radiation and heat : a novel multi-hit-repair approach. Computational and Mathematical Methods in Medicine. 2013. Bd. 2013, Nr. 587543. DOI 10.21256/zhaw-1765
Scheidegger, Stephan, Hans Ulrich Fuchs, Kathrin Zaugg, Stephan Bodis, and Rudolf Marcel Füchslin. 2013. “Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach.” Computational and Mathematical Methods in Medicine 2013 (587543). https://doi.org/10.21256/zhaw-1765.
Scheidegger, Stephan, et al. “Using State Variables to Model the Response of Tumour Cells to Radiation and Heat : A Novel Multi-Hit-Repair Approach.” Computational and Mathematical Methods in Medicine, vol. 2013, no. 587543, 2013, https://doi.org/10.21256/zhaw-1765.
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