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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Tissue Engineering - the gateway to regenerative medicine
Authors: Bono, Epifania
Mathes, Stephanie H
Franscini, Nicola
Graf-Hausner, Ursula
DOI: 10.21256/zhaw-1754
Published in: Chimia
Editors of the parent work: Alexakis, Domenico P.
Volume(Issue): 64
Issue: 11
Page(s): 808
Pages to: 812
Issue Date: Nov-2010
Publisher / Ed. Institution: Schweizerische Chemische Gesellschaft
Publisher / Ed. Institution: Bern
ISSN: 0009-4293
Language: English
Subjects: Icbc; Automation; Biomaterials; Disc regeneration; Soft tissue; Tissue regeneration
Subject (DDC): 616: Internal medicine and diseases
Abstract: Tissue Engineering as an emerging biotechnology sector aims at the in vitro regeneration of diseased tissues and promises to profoundly change medical practice, offering the possibility of regenerating tissues and organs instead of just repairing them (regenerative medicine). Improved healing processes and a higher quality of life are the expected results. This article gives an overview of different technologies for regenerative medicine and presents results of our own current applied research and development. A recent project was successfully closed with the development of a natural biomaterial for soft tissue oral defects. The establishment of an in vitro bioreactor system enabled us to simulate the mechanical and biological environment in a healing wound and to investigate the suitability of different implant materials for the oral tissue regeneration. Moreover, focusing the attention on an alternative method for the intervertebral disc (IVD) regeneration, we established a new tissue engineered approach, based on the three-dimensional (3D) culture of autologous human IVD cells into a polyurethane (PU)-fibrin composite. IVD cells were able to proliferate and, thanks to the 3D conditions, to differentiate expressing the typical native tissue markers. The development of an automated platform was the goal of an additional project, to standardize the cell culture technology, increase the bio-safety and reduce the production costs, moving tissue engineering nearer to clinical application.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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Bono, E., Mathes, S. H., Franscini, N., & Graf-Hausner, U. (2010). Tissue Engineering - the gateway to regenerative medicine. Chimia, 64(11), 808–812.
Bono, E. et al. (2010) ‘Tissue Engineering - the gateway to regenerative medicine’, Chimia. Edited by D.P. Alexakis, 64(11), pp. 808–812. Available at:
E. Bono, S. H. Mathes, N. Franscini, and U. Graf-Hausner, “Tissue Engineering - the gateway to regenerative medicine,” Chimia, vol. 64, no. 11, pp. 808–812, Nov. 2010, doi: 10.21256/zhaw-1754.
BONO, Epifania, Stephanie H MATHES, Nicola FRANSCINI und Ursula GRAF-HAUSNER, 2010. Tissue Engineering - the gateway to regenerative medicine. Domenico P. ALEXAKIS (Hrsg.), Chimia. November 2010. Bd. 64, Nr. 11, S. 808–812. DOI 10.21256/zhaw-1754
Bono, Epifania, Stephanie H Mathes, Nicola Franscini, and Ursula Graf-Hausner. 2010. “Tissue Engineering - the Gateway to Regenerative Medicine.” Edited by Domenico P. Alexakis. Chimia 64 (11): 808–12.
Bono, Epifania, et al. “Tissue Engineering - the Gateway to Regenerative Medicine.” Chimia, edited by Domenico P. Alexakis, vol. 64, no. 11, Nov. 2010, pp. 808–12,

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