Title: Covalent binding of biorecognition groups to solids using poly(hydromethylsiloxane) as linkage
Authors : Zhang, Xuequn
Deckert, Volker
Steiger, Beat
Hirayama, Martina
Suter, Ulrich
Pretsch, Ernö
Published in : Talanta
Volume(Issue) : 63
Issue : 1
Pages : 159
Pages to: 165
Publisher / Ed. Institution : Elsevier
Publisher / Ed. Institution: Amsterdam
Issue Date: May-2004
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Polysiloxane; Biosensor; Biorecognition; Immobilization
Subject (DDC) : 540: Chemistry
Abstract: By activating Si-H bonds, poly(hydromethylsiloxane) can be covalently bound in a first step to various metal or polymer surfaces. In a second step, unreacted Si-H bonds can be brought to react with organic compounds having adequate functional groups such as double or triple bonds, carbonyl or hydroxyl groups. This scheme is used to bind biorecognition groups to solids. The novel concept is demonstrated by attaching a newly synthesized biotin derivative to Au. It is shown that the immobilized biotin is capable of binding streptavidin.
Departement: School of Engineering
Publication type: Article in scientific Journal
DOI : 10.1016/j.talanta.2003.11.043
ISSN: 0039-9140
URI: https://digitalcollection.zhaw.ch/handle/11475/3025
Appears in Collections:Publikationen School of Engineering

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