|Title:||Covalent binding of biorecognition groups to solids using poly(hydromethylsiloxane) as linkage|
|Authors :||Zhang, Xuequn|
|Published in :||Talanta|
|Publisher / Ed. Institution :||Elsevier|
|Publisher / Ed. Institution:||Amsterdam|
|License (according to publishing contract) :||Licence according to publishing contract|
|Type of review:||Peer review (Publication)|
|Subjects :||Polysiloxane; Biosensor; Biorecognition; Immobilization|
|Subject (DDC) :||540: Chemistry|
|Abstract:||By activating Si-H bonds, poly(hydromethylsiloxane) can be covalently bound in a first step to various metal or polymer surfaces. In a second step, unreacted Si-H bonds can be brought to react with organic compounds having adequate functional groups such as double or triple bonds, carbonyl or hydroxyl groups. This scheme is used to bind biorecognition groups to solids. The novel concept is demonstrated by attaching a newly synthesized biotin derivative to Au. It is shown that the immobilized biotin is capable of binding streptavidin.|
|Departement:||School of Engineering|
|Publication type:||Article in scientific Journal|
|Appears in Collections:||Publikationen School of Engineering|
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