Photostability of sennosides and their aglycones in solution

Meier, Nadja; Meier, Beat; Schenk, Alexander; Ziegler, Le Nhung; Peter, Samuel; Wolfram, Evelyn

doi:10.1002/pca.3308

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Photostability of sennosides and their aglycones in solution
Authors:	Meier, Nadja Meier, Beat Schenk, Alexander Ziegler, Le Nhung Peter, Samuel Wolfram, Evelyn
et. al:	No
DOI:	10.1002/pca.3308
Published in:	Phytochemical Analysis
Issue Date:	10-Jan-2024
Publisher / Ed. Institution:	Wiley
ISSN:	1099-1565 0958-0344
Language:	English
Subjects:	Senna alexandrina; Aglycone; Photostability; Rhein; Sennosides
Subject (DDC):	572: Biochemistry
Abstract:	Introduction: Sennosides are the main active constituents of the dried leaves and/or pods of Senna alexandrina Mill. that are used as laxatives. A hypothesis is that aglycones are formed during the degradation of sennosides. However, it is unknown, whether this happens under visible light exposure and how photosensitive sennosides behave in solution. Objectives: Pure anthraquinone glycosides were tested on their behaviour during sample preparation in the lab under visible light exposure in dependence on the instability of the solvent. Materials and methods: Samples before and after exposure were analysed using UHPLC with UV/Vis and MS detection. Results: Under visible light protection, the solutions were stable for 14 days at room temperature whereas a loss of 20%–60% was measured after 1 day of light exposure. The loss of sennosides due to degradation can be as fast as up to 2%–2.5% per hour, which might have a tremendous impact on phytochemical analysis results during the course of an analysis. The formation of aglycones was not observed in the degradation of sennosides and rhein-8-O-glucoside. Conclusion: Aglycones could not be found as a result of the forced degradation. The solutions of sennosides clearly need to be protected from light to obtain reliable analytical results, and light protection is a major point for the stability of liquid preparations.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29642
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Meier, N., Meier, B., Schenk, A., Ziegler, L. N., Peter, S., & Wolfram, E. (2024). Photostability of sennosides and their aglycones in solution. Phytochemical Analysis. https://doi.org/10.1002/pca.3308

Meier, N. et al. (2024) ‘Photostability of sennosides and their aglycones in solution’, Phytochemical Analysis [Preprint]. Available at: https://doi.org/10.1002/pca.3308.

N. Meier, B. Meier, A. Schenk, L. N. Ziegler, S. Peter, and E. Wolfram, “Photostability of sennosides and their aglycones in solution,” Phytochemical Analysis, Jan. 2024, doi: 10.1002/pca.3308.

MEIER, Nadja, Beat MEIER, Alexander SCHENK, Le Nhung ZIEGLER, Samuel PETER und Evelyn WOLFRAM, 2024. Photostability of sennosides and their aglycones in solution. Phytochemical Analysis. 10 Januar 2024. DOI 10.1002/pca.3308

Meier, Nadja, Beat Meier, Alexander Schenk, Le Nhung Ziegler, Samuel Peter, and Evelyn Wolfram. 2024. “Photostability of Sennosides and Their Aglycones in Solution.” Phytochemical Analysis, January. https://doi.org/10.1002/pca.3308.

Meier, Nadja, et al. “Photostability of Sennosides and Their Aglycones in Solution.” Phytochemical Analysis, Jan. 2024, https://doi.org/10.1002/pca.3308.