1. ZHAW digitalcollection
  2. Life Sciences und Facility Management
  3. Publikationen
  4. Publikationen Life Sciences und Facility Management
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMeier, Nadja-
dc.contributor.authorMeier, Beat-
dc.contributor.authorSchenk, Alexander-
dc.contributor.authorZiegler, Le Nhung-
dc.contributor.authorPeter, Samuel-
dc.contributor.authorWolfram, Evelyn-
dc.date.accessioned2024-01-19T10:36:32Z-
dc.date.available2024-01-19T10:36:32Z-
dc.date.issued2024-01-10-
dc.identifier.issn1099-1565de_CH
dc.identifier.issn0958-0344 de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/29642-
dc.description.abstractIntroduction: Sennosides are the main active constituents of the dried leaves and/or pods of Senna alexandrina Mill. that are used as laxatives. A hypothesis is that aglycones are formed during the degradation of sennosides. However, it is unknown, whether this happens under visible light exposure and how photosensitive sennosides behave in solution. Objectives: Pure anthraquinone glycosides were tested on their behaviour during sample preparation in the lab under visible light exposure in dependence on the instability of the solvent. Materials and methods: Samples before and after exposure were analysed using UHPLC with UV/Vis and MS detection. Results: Under visible light protection, the solutions were stable for 14 days at room temperature whereas a loss of 20%–60% was measured after 1 day of light exposure. The loss of sennosides due to degradation can be as fast as up to 2%–2.5% per hour, which might have a tremendous impact on phytochemical analysis results during the course of an analysis. The formation of aglycones was not observed in the degradation of sennosides and rhein-8-O-glucoside. Conclusion: Aglycones could not be found as a result of the forced degradation. The solutions of sennosides clearly need to be protected from light to obtain reliable analytical results, and light protection is a major point for the stability of liquid preparations.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofPhytochemical Analysisde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectSenna alexandrinade_CH
dc.subjectAglyconede_CH
dc.subjectPhotostabilityde_CH
dc.subjectRheinde_CH
dc.subjectSennosidesde_CH
dc.subject.ddc572: Biochemiede_CH
dc.titlePhotostability of sennosides and their aglycones in solutionde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1002/pca.3308de_CH
dc.identifier.pmid38198752de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPhytopharmaziede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
There are no files associated with this item.
Show simple item record
Meier, N., Meier, B., Schenk, A., Ziegler, L. N., Peter, S., & Wolfram, E. (2024). Photostability of sennosides and their aglycones in solution. Phytochemical Analysis. https://doi.org/10.1002/pca.3308
Meier, N. et al. (2024) ‘Photostability of sennosides and their aglycones in solution’, Phytochemical Analysis [Preprint]. Available at: https://doi.org/10.1002/pca.3308.
N. Meier, B. Meier, A. Schenk, L. N. Ziegler, S. Peter, and E. Wolfram, “Photostability of sennosides and their aglycones in solution,” Phytochemical Analysis, Jan. 2024, doi: 10.1002/pca.3308.
MEIER, Nadja, Beat MEIER, Alexander SCHENK, Le Nhung ZIEGLER, Samuel PETER und Evelyn WOLFRAM, 2024. Photostability of sennosides and their aglycones in solution. Phytochemical Analysis. 10 Januar 2024. DOI 10.1002/pca.3308
Meier, Nadja, Beat Meier, Alexander Schenk, Le Nhung Ziegler, Samuel Peter, and Evelyn Wolfram. 2024. “Photostability of Sennosides and Their Aglycones in Solution.” Phytochemical Analysis, January. https://doi.org/10.1002/pca.3308.
Meier, Nadja, et al. “Photostability of Sennosides and Their Aglycones in Solution.” Phytochemical Analysis, Jan. 2024, https://doi.org/10.1002/pca.3308.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.