Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-1696| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | Diastereoselective synthesis of optically active (2R,5R)-hexanediol |
| Authors: | Haberland, Jürgen Kriegesmann, A. Wolfram, Evelyn Hummel, Werner Liese, Andreas |
| DOI: | 10.21256/zhaw-1696 10.1007/s00253-002-0936-5 |
| Published in: | Applied Microbiology and Biotechnology |
| Volume(Issue): | 58 |
| Issue: | 5 |
| Page(s): | 595 |
| Pages to: | 599 |
| Issue Date: | 2002 |
| Publisher / Ed. Institution: | Springer |
| ISSN: | 0175-7598 1432-0614 |
| Language: | English |
| Subjects: | Biomass; Hexanedione; Lactobacillus; Maximal Yield; Biomass Concentration |
| Subject (DDC): | 570: Biology 660.6: Biotechnology |
| Abstract: | Diastereoselective reduction of diketones with Lactobacillus kefir DSM 20587 was examined. The reduction of both oxo-functions proceeded highly diastereoselectively. (2R,5R)-Hexanediol 3 was produced starting from (2,5)-hexanedione 1 in quantitative yields with enantiomeric excess >99% and diastereomeric excess >99%. The reaction conditions were optimized: maximum yield of (2R,5R)-hexanediol was reached at pH 6, 30°C and with equal amounts of substrate and cosubstrate. The applicability of the system in fed-batch experiments was demonstrated. The feed specific biomass concentration required to reach maximal yield and selectivity in fed-batch mode was determined. |
| Further description: | Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch) |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2963 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2002_Haberland_Diastereoselective synthesis_Applied Microbiology and Biotechnology.pdf | 152.29 kB | Adobe PDF |  View/Open |
Show full item record
Haberland, J., Kriegesmann, A., Wolfram, E., Hummel, W., & Liese, A. (2002). Diastereoselective synthesis of optically active (2R,5R)-hexanediol. Applied Microbiology and Biotechnology, 58(5), 595–599. https://doi.org/10.21256/zhaw-1696
Haberland, J. et al. (2002) ‘Diastereoselective synthesis of optically active (2R,5R)-hexanediol’, Applied Microbiology and Biotechnology, 58(5), pp. 595–599. Available at: https://doi.org/10.21256/zhaw-1696.
J. Haberland, A. Kriegesmann, E. Wolfram, W. Hummel, and A. Liese, “Diastereoselective synthesis of optically active (2R,5R)-hexanediol,” Applied Microbiology and Biotechnology, vol. 58, no. 5, pp. 595–599, 2002, doi: 10.21256/zhaw-1696.
HABERLAND, Jürgen, A. KRIEGESMANN, Evelyn WOLFRAM, Werner HUMMEL und Andreas LIESE, 2002. Diastereoselective synthesis of optically active (2R,5R)-hexanediol. Applied Microbiology and Biotechnology. 2002. Bd. 58, Nr. 5, S. 595–599. DOI 10.21256/zhaw-1696
Haberland, Jürgen, A. Kriegesmann, Evelyn Wolfram, Werner Hummel, and Andreas Liese. 2002. “Diastereoselective Synthesis of Optically Active (2R,5R)-Hexanediol.” Applied Microbiology and Biotechnology 58 (5): 595–99. https://doi.org/10.21256/zhaw-1696.
Haberland, Jürgen, et al. “Diastereoselective Synthesis of Optically Active (2R,5R)-Hexanediol.” Applied Microbiology and Biotechnology, vol. 58, no. 5, 2002, pp. 595–99, https://doi.org/10.21256/zhaw-1696.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.