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Title: Diastereoselective synthesis of optically active (2R,5R)-hexanediol
Authors : Haberland, Jürgen
Kriegesmann, A.
Wolfram, Evelyn
Hummel, Werner
Liese, Andreas
Published in : Applied Microbiology and Biotechnology
Volume(Issue) : 58
Issue : 5
Pages : 595
Pages to: 599
Publisher / Ed. Institution : Springer
Issue Date: 2002
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Biomass; Hexanedione; Lactobacillus; Maximal Yield; Biomass Concentration
Subject (DDC) : 570: Biology
660.6: Biotechnology
Abstract: Diastereoselective reduction of diketones with Lactobacillus kefir DSM 20587 was examined. The reduction of both oxo-functions proceeded highly diastereoselectively. (2R,5R)-Hexanediol 3 was produced starting from (2,5)-hexanedione 1 in quantitative yields with enantiomeric excess >99% and diastereomeric excess >99%. The reaction conditions were optimized: maximum yield of (2R,5R)-hexanediol was reached at pH 6, 30°C and with equal amounts of substrate and cosubstrate. The applicability of the system in fed-batch experiments was demonstrated. The feed specific biomass concentration required to reach maximal yield and selectivity in fed-batch mode was determined.
Further description : Erworben im Rahmen der Schweizer Nationallizenzen (
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1007/s00253-002-0936-5
ISSN: 0175-7598
Appears in Collections:Publikationen Life Sciences und Facility Management

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