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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-1696
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dc.contributor.authorHaberland, Jürgen-
dc.contributor.authorKriegesmann, A.-
dc.contributor.authorWolfram, Evelyn-
dc.contributor.authorHummel, Werner-
dc.contributor.authorLiese, Andreas-
dc.date.accessioned2018-02-22T15:43:45Z-
dc.date.available2018-02-22T15:43:45Z-
dc.date.issued2002-
dc.identifier.issn0175-7598de_CH
dc.identifier.issn1432-0614de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2963-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)de_CH
dc.description.abstractDiastereoselective reduction of diketones with Lactobacillus kefir DSM 20587 was examined. The reduction of both oxo-functions proceeded highly diastereoselectively. (2R,5R)-Hexanediol 3 was produced starting from (2,5)-hexanedione 1 in quantitative yields with enantiomeric excess >99% and diastereomeric excess >99%. The reaction conditions were optimized: maximum yield of (2R,5R)-hexanediol was reached at pH 6, 30°C and with equal amounts of substrate and cosubstrate. The applicability of the system in fed-batch experiments was demonstrated. The feed specific biomass concentration required to reach maximal yield and selectivity in fed-batch mode was determined.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofApplied Microbiology and Biotechnologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBiomassde_CH
dc.subjectHexanedionede_CH
dc.subjectLactobacillusde_CH
dc.subjectMaximal Yieldde_CH
dc.subjectBiomass Concentrationde_CH
dc.subject.ddc570: Biologiede_CH
dc.subject.ddc660.6: Biotechnologiede_CH
dc.titleDiastereoselective synthesis of optically active (2R,5R)-hexanediolde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.21256/zhaw-1696-
dc.identifier.doi10.1007/s00253-002-0936-5de_CH
zhaw.funding.euNode_CH
zhaw.issue5de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end599de_CH
zhaw.pages.start595de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume58de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Haberland, J., Kriegesmann, A., Wolfram, E., Hummel, W., & Liese, A. (2002). Diastereoselective synthesis of optically active (2R,5R)-hexanediol. Applied Microbiology and Biotechnology, 58(5), 595–599. https://doi.org/10.21256/zhaw-1696
Haberland, J. et al. (2002) ‘Diastereoselective synthesis of optically active (2R,5R)-hexanediol’, Applied Microbiology and Biotechnology, 58(5), pp. 595–599. Available at: https://doi.org/10.21256/zhaw-1696.
J. Haberland, A. Kriegesmann, E. Wolfram, W. Hummel, and A. Liese, “Diastereoselective synthesis of optically active (2R,5R)-hexanediol,” Applied Microbiology and Biotechnology, vol. 58, no. 5, pp. 595–599, 2002, doi: 10.21256/zhaw-1696.
HABERLAND, Jürgen, A. KRIEGESMANN, Evelyn WOLFRAM, Werner HUMMEL und Andreas LIESE, 2002. Diastereoselective synthesis of optically active (2R,5R)-hexanediol. Applied Microbiology and Biotechnology. 2002. Bd. 58, Nr. 5, S. 595–599. DOI 10.21256/zhaw-1696
Haberland, Jürgen, A. Kriegesmann, Evelyn Wolfram, Werner Hummel, and Andreas Liese. 2002. “Diastereoselective Synthesis of Optically Active (2R,5R)-Hexanediol.” Applied Microbiology and Biotechnology 58 (5): 595–99. https://doi.org/10.21256/zhaw-1696.
Haberland, Jürgen, et al. “Diastereoselective Synthesis of Optically Active (2R,5R)-Hexanediol.” Applied Microbiology and Biotechnology, vol. 58, no. 5, 2002, pp. 595–99, https://doi.org/10.21256/zhaw-1696.


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