Title: Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed
Authors : Pietsch-Schmied, Constanze
Katzenback, Barbara A.
Garcia-Garcia, Erick
Schulz, Carsten
Belosevic, Miodrag
Burkhardt-Holm, Patricia
Published in : Mycotoxin Research
Volume(Issue) : 31
Issue : 3
Pages : 151
Pages to: 164
Publisher / Ed. Institution : Springer
Publisher / Ed. Institution: Berlin
Issue Date: 2015
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Animals; Arginase; Blood Cell Count; Carps; Cell Survival; Gene Expression; Immunity, Innate; Inflammation; Kidney; Liver; Nitric Oxide; RNA, Messenger; Spleen; Trichothecenes; Animal Feed; Food Contamination
Subject (DDC) : 571: Physiology and related subjects
630: Agriculture
Abstract: The mycotoxin deoxynivalenol (DON) has been shown to regularly occur at relevant concentrations in feed designed for aquaculture use, but little is known about the consequences of its presence on the organisms that consume the DON-contaminated feed. Previous studies indicated a down-regulation of pro-inflammatory responses in carp (Cyprinus carpio L.) after 4 weeks of feeding DON. The present study examined the time course of innate immune responses of carp to orally administered DON. Changes in mRNA levels of immune genes in different organs (head kidney, trunk kidney, spleen, liver, and intestine) were observed indicating immune-modulating properties of DON. The immune-modulatory effects during the acute phase of DON exposure were characterized by the activation of both pro- and anti-inflammatory cytokines and enzymes in carp. The subchronic responses to DON were characterized by activation of arginases culminating in increased arginase activity in head kidney leukocytes after 26 days of DON treatment. These results suggest profound effects of this mycotoxin on fish in aquaculture.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Natural Resource Sciences (IUNR)
Publication type: Article in scientific Journal
DOI : 10.1007/s12550-015-0226-6
ISSN: 0178-7888
URI: https://digitalcollection.zhaw.ch/handle/11475/2847
Appears in Collections:Publikationen Life Sciences und Facility Management

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