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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-2847
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dc.contributor.authorPietsch-Schmied, Constanze-
dc.contributor.authorKatzenback, Barbara A.-
dc.contributor.authorGarcia-Garcia, Erick-
dc.contributor.authorSchulz, Carsten-
dc.contributor.authorBelosevic, Miodrag-
dc.contributor.authorBurkhardt-Holm, Patricia-
dc.date.accessioned2018-02-15T15:31:40Z-
dc.date.available2018-02-15T15:31:40Z-
dc.date.issued2015-
dc.identifier.issn0178-7888de_CH
dc.identifier.issn1867-1632de_CH
dc.identifier.issn1867-1632de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2847-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)de_CH
dc.description.abstractThe mycotoxin deoxynivalenol (DON) has been shown to regularly occur at relevant concentrations in feed designed for aquaculture use, but little is known about the consequences of its presence on the organisms that consume the DON-contaminated feed. Previous studies indicated a down-regulation of pro-inflammatory responses in carp (Cyprinus carpio L.) after 4 weeks of feeding DON. The present study examined the time course of innate immune responses of carp to orally administered DON. Changes in mRNA levels of immune genes in different organs (head kidney, trunk kidney, spleen, liver, and intestine) were observed indicating immune-modulating properties of DON. The immune-modulatory effects during the acute phase of DON exposure were characterized by the activation of both pro- and anti-inflammatory cytokines and enzymes in carp. The subchronic responses to DON were characterized by activation of arginases culminating in increased arginase activity in head kidney leukocytes after 26 days of DON treatment. These results suggest profound effects of this mycotoxin on fish in aquaculture.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofMycotoxin Researchde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAnimalde_CH
dc.subjectArginasede_CH
dc.subjectBlood cell countde_CH
dc.subjectCarpde_CH
dc.subjectCell survivalde_CH
dc.subjectGene expressionde_CH
dc.subjectImmunity, innatede_CH
dc.subjectInflammationde_CH
dc.subjectKidneyde_CH
dc.subjectLiverde_CH
dc.subjectNitric oxidede_CH
dc.subjectRNA, Messengerde_CH
dc.subjectSpleende_CH
dc.subjectTrichothecenesde_CH
dc.subjectAnimal feedde_CH
dc.subjectFood contaminationde_CH
dc.subject.ddc571: Physiologie und verwandte Themende_CH
dc.subject.ddc630: Landwirtschaftde_CH
dc.titleAcute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feedde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Umwelt und Natürliche Ressourcen (IUNR)de_CH
zhaw.publisher.placeBerlinde_CH
dc.identifier.doi10.1007/s12550-015-0226-6de_CH
dc.identifier.doi10.21256/zhaw-2847-
dc.identifier.pmid25989849de_CH
zhaw.funding.euNode_CH
zhaw.issue3de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end164de_CH
zhaw.pages.start151de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume31de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedAquakultur-Systemede_CH
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Pietsch-Schmied, C., Katzenback, B. A., Garcia-Garcia, E., Schulz, C., Belosevic, M., & Burkhardt-Holm, P. (2015). Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed. Mycotoxin Research, 31(3), 151–164. https://doi.org/10.1007/s12550-015-0226-6
Pietsch-Schmied, C. et al. (2015) ‘Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed’, Mycotoxin Research, 31(3), pp. 151–164. Available at: https://doi.org/10.1007/s12550-015-0226-6.
C. Pietsch-Schmied, B. A. Katzenback, E. Garcia-Garcia, C. Schulz, M. Belosevic, and P. Burkhardt-Holm, “Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed,” Mycotoxin Research, vol. 31, no. 3, pp. 151–164, 2015, doi: 10.1007/s12550-015-0226-6.
PIETSCH-SCHMIED, Constanze, Barbara A. KATZENBACK, Erick GARCIA-GARCIA, Carsten SCHULZ, Miodrag BELOSEVIC und Patricia BURKHARDT-HOLM, 2015. Acute and subchronic effects on immune responses of carp (Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed. Mycotoxin Research. 2015. Bd. 31, Nr. 3, S. 151–164. DOI 10.1007/s12550-015-0226-6
Pietsch-Schmied, Constanze, Barbara A. Katzenback, Erick Garcia-Garcia, Carsten Schulz, Miodrag Belosevic, and Patricia Burkhardt-Holm. 2015. “Acute and Subchronic Effects on Immune Responses of Carp (Cyprinus Carpio L.) After Exposure to Deoxynivalenol (DON) in Feed.” Mycotoxin Research 31 (3): 151–64. https://doi.org/10.1007/s12550-015-0226-6.
Pietsch-Schmied, Constanze, et al. “Acute and Subchronic Effects on Immune Responses of Carp (Cyprinus Carpio L.) After Exposure to Deoxynivalenol (DON) in Feed.” Mycotoxin Research, vol. 31, no. 3, 2015, pp. 151–64, https://doi.org/10.1007/s12550-015-0226-6.


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