Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere's disease

Bächinger, David; Filidoro, Noemi; Naville, Marc; Juchler, Norman; Kurtcuoglu, Vartan; Nadol, Joseph B.; Schuknecht, Bernhard; Kleinjung, Tobias; Veraguth, Dorothe; Eckhard, Andreas H.

doi:10.1038/s41598-023-36479-5

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-28264

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere's disease
Authors:	Bächinger, David Filidoro, Noemi Naville, Marc Juchler, Norman Kurtcuoglu, Vartan Nadol, Joseph B. Schuknecht, Bernhard Kleinjung, Tobias Veraguth, Dorothe Eckhard, Andreas H.
et. al:	No
DOI:	10.1038/s41598-023-36479-5 10.21256/zhaw-28264
Published in:	Scientific Reports
Volume(Issue):	13
Issue:	1
Page(s):	10303
Issue Date:	26-Jun-2023
Publisher / Ed. Institution:	Nature Publishing Group
ISSN:	2045-2322
Language:	English
Subjects:	Human; Temporal bone; Radiography; Magnetic resonance imaging; Meniere disease; Endolymphatic sac
Subject (DDC):	617: Surgery
Abstract:	We aimed to determine the prevalence of radiological temporal bone features that in previous studies showed only a weak or an inconsistent association with the clinical diagnosis of Meniere's disease (MD), in two groups of MD patients (n = 71) with previously established distinct endolymphatic sac pathologies; i.e. the group MD-dg (ES degeneration) and the group MD-hp (ES hypoplasia). Delayed gadolinium-enhanced MRI and high-resolution CT data were used to determine and compare between and within (affected vs. non-affected side) groups geometric temporal bone features (lengths, widths, contours), air cell tract volume, height of the jugular bulb, sigmoid sinus width, and MRI signal intensity alterations of the ES. Temporal bone features with significant intergroup differences were the retrolabyrinthine bone thickness (1.04 ± 0.69 mm, MD-hp; 3.1 ± 1.9 mm, MD-dg; p < 0.0001); posterior contour tortuosity (mean arch-to-chord ratio 1.019 ± 0.013, MD-hp; 1.096 ± 0.038, MD-dg; p < 0.0001); and the pneumatized volume (1.37 [0.86] cm3, MD-hp; 5.25 [3.45] cm3, MD-dg; p = 0.03). Features with differences between the affected and non-affected sides within the MD-dg group were the sigmoid sinus width (6.5 ± 1.7 mm, affected; 7.6 ± 2.1 mm, non-affected; p = 0.04) and the MRI signal intensity of the endolymphatic sac (median signal intensity, affected vs. unaffected side, 0.59 [IQR 0.31-0.89]). Radiological temporal bone features known to be only weakly or inconsistently associated with the clinical diagnosis MD, are highly prevalent in either of two MD patient groups. These results support the existence of diverse-developmental and degenerative-disease etiologies manifesting with distinct radiological temporal bone abnormalities.
URI:	https://digitalcollection.zhaw.ch/handle/11475/28264
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Computational Life Sciences (ICLS)
Appears in collections:	Publikationen Life Sciences und Facility Management

Files in This Item:

File	Description	Size	Format
2023_Baechinger-etal_Radiological-feature-heterogeneity-supports-etiological-diversity-Meniers-disease.pdf	Article as published online June 26, 2023	6.33 MB	Adobe PDF	View/Open

Show full item record

Bächinger, D., Filidoro, N., Naville, M., Juchler, N., Kurtcuoglu, V., Nadol, J. B., Schuknecht, B., Kleinjung, T., Veraguth, D., & Eckhard, A. H. (2023). Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease. Scientific Reports, 13(1), 10303. https://doi.org/10.1038/s41598-023-36479-5

Bächinger, D. et al. (2023) ‘Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease’, Scientific Reports, 13(1), p. 10303. Available at: https://doi.org/10.1038/s41598-023-36479-5.

D. Bächinger et al., “Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease,” Scientific Reports, vol. 13, no. 1, p. 10303, Jun. 2023, doi: 10.1038/s41598-023-36479-5.

BÄCHINGER, David, Noemi FILIDORO, Marc NAVILLE, Norman JUCHLER, Vartan KURTCUOGLU, Joseph B. NADOL, Bernhard SCHUKNECHT, Tobias KLEINJUNG, Dorothe VERAGUTH und Andreas H. ECKHARD, 2023. Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease. Scientific Reports. 26 Juni 2023. Bd. 13, Nr. 1, S. 10303. DOI 10.1038/s41598-023-36479-5

Bächinger, David, Noemi Filidoro, Marc Naville, Norman Juchler, Vartan Kurtcuoglu, Joseph B. Nadol, Bernhard Schuknecht, Tobias Kleinjung, Dorothe Veraguth, and Andreas H. Eckhard. 2023. “Radiological Feature Heterogeneity Supports Etiological Diversity among Patient Groups in Meniere’s Disease.” Scientific Reports 13 (1): 10303. https://doi.org/10.1038/s41598-023-36479-5.

Bächinger, David, et al. “Radiological Feature Heterogeneity Supports Etiological Diversity among Patient Groups in Meniere’s Disease.” Scientific Reports, vol. 13, no. 1, June 2023, p. 10303, https://doi.org/10.1038/s41598-023-36479-5.