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https://doi.org/10.21256/zhaw-28264| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere's disease |
| Autor/-in: | Bächinger, David Filidoro, Noemi Naville, Marc Juchler, Norman Kurtcuoglu, Vartan Nadol, Joseph B. Schuknecht, Bernhard Kleinjung, Tobias Veraguth, Dorothe Eckhard, Andreas H. |
| et. al: | No |
| DOI: | 10.1038/s41598-023-36479-5 10.21256/zhaw-28264 |
| Erschienen in: | Scientific Reports |
| Band(Heft): | 13 |
| Heft: | 1 |
| Seite(n): | 10303 |
| Erscheinungsdatum: | 26-Jun-2023 |
| Verlag / Hrsg. Institution: | Nature Publishing Group |
| ISSN: | 2045-2322 |
| Sprache: | Englisch |
| Schlagwörter: | Human; Temporal bone; Radiography; Magnetic resonance imaging; Meniere disease; Endolymphatic sac |
| Fachgebiet (DDC): | 617: Chirurgie |
| Zusammenfassung: | We aimed to determine the prevalence of radiological temporal bone features that in previous studies showed only a weak or an inconsistent association with the clinical diagnosis of Meniere's disease (MD), in two groups of MD patients (n = 71) with previously established distinct endolymphatic sac pathologies; i.e. the group MD-dg (ES degeneration) and the group MD-hp (ES hypoplasia). Delayed gadolinium-enhanced MRI and high-resolution CT data were used to determine and compare between and within (affected vs. non-affected side) groups geometric temporal bone features (lengths, widths, contours), air cell tract volume, height of the jugular bulb, sigmoid sinus width, and MRI signal intensity alterations of the ES. Temporal bone features with significant intergroup differences were the retrolabyrinthine bone thickness (1.04 ± 0.69 mm, MD-hp; 3.1 ± 1.9 mm, MD-dg; p < 0.0001); posterior contour tortuosity (mean arch-to-chord ratio 1.019 ± 0.013, MD-hp; 1.096 ± 0.038, MD-dg; p < 0.0001); and the pneumatized volume (1.37 [0.86] cm3, MD-hp; 5.25 [3.45] cm3, MD-dg; p = 0.03). Features with differences between the affected and non-affected sides within the MD-dg group were the sigmoid sinus width (6.5 ± 1.7 mm, affected; 7.6 ± 2.1 mm, non-affected; p = 0.04) and the MRI signal intensity of the endolymphatic sac (median signal intensity, affected vs. unaffected side, 0.59 [IQR 0.31-0.89]). Radiological temporal bone features known to be only weakly or inconsistently associated with the clinical diagnosis MD, are highly prevalent in either of two MD patient groups. These results support the existence of diverse-developmental and degenerative-disease etiologies manifesting with distinct radiological temporal bone abnormalities. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/28264 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Computational Life Sciences (ICLS) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2023_Baechinger-etal_Radiological-feature-heterogeneity-supports-etiological-diversity-Meniers-disease.pdf | Article as published online June 26, 2023 | 6.33 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Bächinger, D., Filidoro, N., Naville, M., Juchler, N., Kurtcuoglu, V., Nadol, J. B., Schuknecht, B., Kleinjung, T., Veraguth, D., & Eckhard, A. H. (2023). Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease. Scientific Reports, 13(1), 10303. https://doi.org/10.1038/s41598-023-36479-5
Bächinger, D. et al. (2023) ‘Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease’, Scientific Reports, 13(1), p. 10303. Available at: https://doi.org/10.1038/s41598-023-36479-5.
D. Bächinger et al., “Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease,” Scientific Reports, vol. 13, no. 1, p. 10303, Jun. 2023, doi: 10.1038/s41598-023-36479-5.
BÄCHINGER, David, Noemi FILIDORO, Marc NAVILLE, Norman JUCHLER, Vartan KURTCUOGLU, Joseph B. NADOL, Bernhard SCHUKNECHT, Tobias KLEINJUNG, Dorothe VERAGUTH und Andreas H. ECKHARD, 2023. Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere’s disease. Scientific Reports. 26 Juni 2023. Bd. 13, Nr. 1, S. 10303. DOI 10.1038/s41598-023-36479-5
Bächinger, David, Noemi Filidoro, Marc Naville, Norman Juchler, Vartan Kurtcuoglu, Joseph B. Nadol, Bernhard Schuknecht, Tobias Kleinjung, Dorothe Veraguth, and Andreas H. Eckhard. 2023. “Radiological Feature Heterogeneity Supports Etiological Diversity among Patient Groups in Meniere’s Disease.” Scientific Reports 13 (1): 10303. https://doi.org/10.1038/s41598-023-36479-5.
Bächinger, David, et al. “Radiological Feature Heterogeneity Supports Etiological Diversity among Patient Groups in Meniere’s Disease.” Scientific Reports, vol. 13, no. 1, June 2023, p. 10303, https://doi.org/10.1038/s41598-023-36479-5.
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