Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: A naked eye-invisible ratiometric fluorescent microneedle tattoo for real-time monitoring of inflammatory skin conditions
Authors: Babity, Samuel
Couture, Frédéric
Campos, Estefânia V R
Hedtrich, Sarah
Hagen, Raphael
Fehr, Daniel
Bonmarin, Mathias
Brambilla, Davide
et. al: No
DOI: 10.1002/adhm.202102070
Published in: Advanced Healthcare Materials
Volume(Issue): 11
Issue: 6
Page(s): 2102070
Issue Date: 17-Dec-2021
Publisher / Ed. Institution: Wiley
ISSN: 2192-2640
Language: English
Subjects: ROS; Diagnostics; Inflammatory skin disease; Microneedle; Tattoo
Subject (DDC): 610.28: Biomedicine, biomedical engineering
Abstract: The field of portable healthcare monitoring devices has an urgent need for the development of real-time, noninvasive sensing and detection methods for various physiological analytes. Currently, transdermal sensing techniques are severely limited in scope (i.e., measurement of heart rate or sweat composition), or else tend to be invasive, often needing to be performed in a clinical setting. This study proposes a minimally invasive alternative strategy, consisting of using dissolving polymeric microneedles to deliver naked eye-invisible functional fluorescent ratiometric microneedle tattoos directly to the skin for real-time monitoring and quantification of physiological and pathological parameters. Reactive oxygen species are overexpressed in the skin in association with various pathological conditions. Here, one demonstrates for the first time the microneedle-based delivery to the skin of active fluorescent sensors in the form of an invisible, ratiometric microneedle tattoo capable of sensing reactive oxygen species in a reconstructed human-based skin disease model, as well as an in vivo model of UV-induced dermal inflammation. One also elaborates a universal ratiometric quantification concept coupled with a custom-built, multiwavelength portable fluorescence detection system. Fully realized, this approach presents an opportunity for the minimally invasive monitoring of a broad range of physiological parameters through the skin.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: School of Engineering
Organisational Unit: Institute of Computational Physics (ICP)
Published as part of the ZHAW project: Development of a portable fluorescence measurement device
Appears in collections:Publikationen School of Engineering

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