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  2. School of Engineering
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  4. Publikationen School of Engineering
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dc.contributor.authorBabity, Samuel-
dc.contributor.authorCouture, Frédéric-
dc.contributor.authorCampos, Estefânia V R-
dc.contributor.authorHedtrich, Sarah-
dc.contributor.authorHagen, Raphael-
dc.contributor.authorFehr, Daniel-
dc.contributor.authorBonmarin, Mathias-
dc.contributor.authorBrambilla, Davide-
dc.date.accessioned2022-01-07T11:58:42Z-
dc.date.available2022-01-07T11:58:42Z-
dc.date.issued2021-12-17-
dc.identifier.issn2192-2640de_CH
dc.identifier.issn2192-2659de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/23851-
dc.description.abstractThe field of portable healthcare monitoring devices has an urgent need for the development of real-time, noninvasive sensing and detection methods for various physiological analytes. Currently, transdermal sensing techniques are severely limited in scope (i.e., measurement of heart rate or sweat composition), or else tend to be invasive, often needing to be performed in a clinical setting. This study proposes a minimally invasive alternative strategy, consisting of using dissolving polymeric microneedles to deliver naked eye-invisible functional fluorescent ratiometric microneedle tattoos directly to the skin for real-time monitoring and quantification of physiological and pathological parameters. Reactive oxygen species are overexpressed in the skin in association with various pathological conditions. Here, one demonstrates for the first time the microneedle-based delivery to the skin of active fluorescent sensors in the form of an invisible, ratiometric microneedle tattoo capable of sensing reactive oxygen species in a reconstructed human-based skin disease model, as well as an in vivo model of UV-induced dermal inflammation. One also elaborates a universal ratiometric quantification concept coupled with a custom-built, multiwavelength portable fluorescence detection system. Fully realized, this approach presents an opportunity for the minimally invasive monitoring of a broad range of physiological parameters through the skin.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofAdvanced Healthcare Materialsde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectROSde_CH
dc.subjectDiagnosticsde_CH
dc.subjectInflammatory skin diseasede_CH
dc.subjectMicroneedlede_CH
dc.subjectTattoode_CH
dc.subject.ddc610.28: Biomedizin, Biomedizinische Technikde_CH
dc.titleA naked eye-invisible ratiometric fluorescent microneedle tattoo for real-time monitoring of inflammatory skin conditionsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitute of Computational Physics (ICP)de_CH
dc.identifier.doi10.1002/adhm.202102070de_CH
dc.identifier.pmid34921529de_CH
zhaw.funding.euNode_CH
zhaw.issue6de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start2102070de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume11de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedSensors and Measuring Systemsde_CH
zhaw.funding.zhawDevelopment of a portable fluorescence measurement devicede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Babity, S., Couture, F., Campos, E. V. R., Hedtrich, S., Hagen, R., Fehr, D., Bonmarin, M., & Brambilla, D. (2021). A naked eye-invisible ratiometric fluorescent microneedle tattoo for real-time monitoring of inflammatory skin conditions. Advanced Healthcare Materials, 11(6), 2102070. https://doi.org/10.1002/adhm.202102070
Babity, S. et al. (2021) ‘A naked eye-invisible ratiometric fluorescent microneedle tattoo for real-time monitoring of inflammatory skin conditions’, Advanced Healthcare Materials, 11(6), p. 2102070. Available at: https://doi.org/10.1002/adhm.202102070.
S. Babity et al., “A naked eye-invisible ratiometric fluorescent microneedle tattoo for real-time monitoring of inflammatory skin conditions,” Advanced Healthcare Materials, vol. 11, no. 6, p. 2102070, Dec. 2021, doi: 10.1002/adhm.202102070.
BABITY, Samuel, Frédéric COUTURE, Estefânia V R CAMPOS, Sarah HEDTRICH, Raphael HAGEN, Daniel FEHR, Mathias BONMARIN und Davide BRAMBILLA, 2021. A naked eye-invisible ratiometric fluorescent microneedle tattoo for real-time monitoring of inflammatory skin conditions. Advanced Healthcare Materials. 17 Dezember 2021. Bd. 11, Nr. 6, S. 2102070. DOI 10.1002/adhm.202102070
Babity, Samuel, Frédéric Couture, Estefânia V R Campos, Sarah Hedtrich, Raphael Hagen, Daniel Fehr, Mathias Bonmarin, and Davide Brambilla. 2021. “A Naked Eye-Invisible Ratiometric Fluorescent Microneedle Tattoo for Real-Time Monitoring of Inflammatory Skin Conditions.” Advanced Healthcare Materials 11 (6): 2102070. https://doi.org/10.1002/adhm.202102070.
Babity, Samuel, et al. “A Naked Eye-Invisible Ratiometric Fluorescent Microneedle Tattoo for Real-Time Monitoring of Inflammatory Skin Conditions.” Advanced Healthcare Materials, vol. 11, no. 6, Dec. 2021, p. 2102070, https://doi.org/10.1002/adhm.202102070.


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