Title: Bag bioreactor based on wave-induced motion : characteristics and applications
Authors : Eibl-Schindler, Regine
Werner, Sören
Eibl, Dieter
Published in : Advances in Biochemical Engineering/Biotechnology
Pages : 55
Pages to: 87
Editors of the parent work: Eibl-Schindler, Regine
Eibl, Dieter
Publisher / Ed. Institution : Springer
Publisher / Ed. Institution: Berlin
Issue Date: 2010
License (according to publishing contract) : Licence according to publishing contract
Series : Advances in Biochemical Engineering/Biotechnology
Series volume: 115
Type of review: Not specified
Language : English
Subjects : Animal cells; Biological insecticides; Biotransformation; Immunomodulator; Plant cells; Seed inoculum; Wave-mixed bag bioreactor
Subject (DDC) : 660: Chemical engineering
Abstract: Today wave-mixed bag bioreactors are common devices in modern biotechnological processes where simple, safe and flexible production has top priority. Numerous studies that have been published on ex vivo generation of cells, viruses and therapeutic agents during the last 10 years have confirmed their suitability and even superiority to stirred bioreactors made from glass or stainless steel for animal as well as plant cell cultivations. In these studies the wave-mixed bag bioreactors enabled middle to high cell density and adequate productivity in laboratory and pilot scale. This mainly results from low-shear conditions and highly efficient oxygen transfer for cell cultures, as demonstrated for the widely used BioWave®.Starting with an overview of wave-mixed bag bioreactors and their common operation strategies, this chapter delineates engineering aspects of BioWave®, which like Wave Reactor™ and BIOSTAT®CultiBag RM originates from the prototype of a wave-mixed bag bioreactor introduced in 1998. Subsequently, the second part of the chapter focuses on reported BioWave® applications. Conditions and results from cultivations with animal cells, plant cells, microbial cells and nematodes are presented and discussed. 
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Book Part
DOI : 10.1007/10_2008_15
ISBN: 978-3-642-01871-8
URI: https://digitalcollection.zhaw.ch/handle/11475/2266
Appears in Collections:Publikationen Life Sciences und Facility Management

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