Publication type: | Article in scientific journal |
Type of review: | Peer review (publication) |
Title: | Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors |
Authors: | Kaiser, Stephan Jossen, Valentin Schirmaier, Carmen Eibl, Dieter Brill, Silke van den Bos, Christian Eibl-Schindler, Regine |
DOI: | 10.1002/cite.201200180 |
Published in: | Chemie Ingenieur Technik |
Volume(Issue): | 85 |
Issue: | 1-2 |
Page(s): | 95 |
Pages to: | 102 |
Issue Date: | Feb-2013 |
Publisher / Ed. Institution: | Wiley |
Publisher / Ed. Institution: | Weinheim |
ISSN: | 0009-286X 1522-2640 |
Language: | English |
Subject (DDC): | 660: Chemical engineering |
Abstract: | The fluid flow and suspension characteristics inside small-scale, stirred, single-use bioreactors were investigated experimentally and by means of computational fluid dynamics. The required impeller speeds for homogenous suspension were determined for two microcarrier types. The shear stress level and turbulence distribution were predicted using a numerical model, which was verified by particle image velocimetry measurements. In subsequent cultivations of primary mesenchymal adipose-derived stem cells, up to 31.4-fold expansion in cell number was achieved for serum concentrations as low as 5 %. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/2239 |
Fulltext version: | Published version |
License (according to publishing contract): | Licence according to publishing contract |
Departement: | Life Sciences and Facility Management |
Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
Appears in collections: | Publikationen Life Sciences und Facility Management |
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Kaiser, S., Jossen, V., Schirmaier, C., Eibl, D., Brill, S., van den Bos, C., & Eibl-Schindler, R. (2013). Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors. Chemie Ingenieur Technik, 85(1-2), 95–102. https://doi.org/10.1002/cite.201200180
Kaiser, S. et al. (2013) ‘Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors’, Chemie Ingenieur Technik, 85(1-2), pp. 95–102. Available at: https://doi.org/10.1002/cite.201200180.
S. Kaiser et al., “Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors,” Chemie Ingenieur Technik, vol. 85, no. 1-2, pp. 95–102, Feb. 2013, doi: 10.1002/cite.201200180.
KAISER, Stephan, Valentin JOSSEN, Carmen SCHIRMAIER, Dieter EIBL, Silke BRILL, Christian VAN DEN BOS und Regine EIBL-SCHINDLER, 2013. Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors. Chemie Ingenieur Technik. Februar 2013. Bd. 85, Nr. 1-2, S. 95–102. DOI 10.1002/cite.201200180
Kaiser, Stephan, Valentin Jossen, Carmen Schirmaier, Dieter Eibl, Silke Brill, Christian van den Bos, and Regine Eibl-Schindler. 2013. “Fluid Flow and Cell Proliferation of Mesenchymal Adipose-Derived Stem Cells in Small-Scale, Stirred, Single-Use Bioreactors.” Chemie Ingenieur Technik 85 (1-2): 95–102. https://doi.org/10.1002/cite.201200180.
Kaiser, Stephan, et al. “Fluid Flow and Cell Proliferation of Mesenchymal Adipose-Derived Stem Cells in Small-Scale, Stirred, Single-Use Bioreactors.” Chemie Ingenieur Technik, vol. 85, no. 1-2, Feb. 2013, pp. 95–102, https://doi.org/10.1002/cite.201200180.
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