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https://doi.org/10.21256/zhaw-21014| Publication type: | Conference poster |
| Type of review: | Not specified |
| Title: | CFD for stirred bioreactors : analysis of different multiphase models to determine oxygen mass transfer |
| Authors: | Seidel, Stefan Werner, Sören Eibl, Dieter |
| et. al: | No |
| DOI: | 10.1002/cite.202055288 10.21256/zhaw-21014 |
| Published in: | Chemie Ingenieur Technik |
| Proceedings: | Special Issue : 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 |
| Page(s): | 1324 |
| Conference details: | 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 : Processes for Future, Web-Konferenz, 21.-24. September 2020 |
| Issue Date: | 24-Sep-2020 |
| Publisher / Ed. Institution: | Wiley |
| ISSN: | 0009-286X |
| Language: | English |
| Subjects: | Bioreactor; CFD simulation; Multiphase modeling; Oxygen transfer rate; Population balance modeling |
| Subject (DDC): | 660: Chemical engineering |
| Abstract: | Oxygen supply of cells has a significant influence on cell growth and product yield. For this reason, biopharmaceutical manufacturers and their bioreactor suppliers are interested in optimizing the oxygen supply. In this context, computational fluid dynamics (CFD) can be used to calculate the kLa value in stirred bioreactors. First investigations have shown that both the volume-of-fluid (VOF) model and the compressible VOF model are unsuitable for the calculation of kLa values due to their lack of accuracy. Simulations with the Euler-Euler model showed significantly better agreement with experimental data, but the calculated kLa values were still about 50% higher than in the experiments. One reason could be the missing consideration of gas bubble breakup and coalescence. Therefore, various investigations were carried out with a population balance model (PBM)-coupled Euler-Euler model, which all were in better agreement with the experimental data, compared to the Euler-Euler model. With the help of the successfully established PBM-coupled CFD model it is now possible to calculate the oxygen mass transfer for stirred bioreactors. Thus, bioreactor and process design can be accomplished before prototyping, and time-consuming as well as cost-intensive laboratory experiments can be reduced. In order to verify the generality for all sizes of bioreactors, further validation work will be carried out. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/21014 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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|---|---|---|---|---|
| 2020_Seidel_et-al_CFD-for-stirred-bioreactors_CITE.pdf | 129.78 kB | Adobe PDF |  View/Open |
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Seidel, S., Werner, S., & Eibl, D. (2020). CFD for stirred bioreactors : analysis of different multiphase models to determine oxygen mass transfer [Conference poster]. Chemie Ingenieur Technik, 1324. https://doi.org/10.1002/cite.202055288
Seidel, S., Werner, S. and Eibl, D. (2020) ‘CFD for stirred bioreactors : analysis of different multiphase models to determine oxygen mass transfer’, in Chemie Ingenieur Technik. Wiley, p. 1324. Available at: https://doi.org/10.1002/cite.202055288.
S. Seidel, S. Werner, and D. Eibl, “CFD for stirred bioreactors : analysis of different multiphase models to determine oxygen mass transfer,” in Chemie Ingenieur Technik, Sep. 2020, p. 1324. doi: 10.1002/cite.202055288.
SEIDEL, Stefan, Sören WERNER und Dieter EIBL, 2020. CFD for stirred bioreactors : analysis of different multiphase models to determine oxygen mass transfer. In: Chemie Ingenieur Technik. Conference poster. Wiley. 24 September 2020. S. 1324
Seidel, Stefan, Sören Werner, and Dieter Eibl. 2020. “CFD for Stirred Bioreactors : Analysis of Different Multiphase Models to Determine Oxygen Mass Transfer.” Conference poster. In Chemie Ingenieur Technik, 1324. Wiley. https://doi.org/10.1002/cite.202055288.
Seidel, Stefan, et al. “CFD for Stirred Bioreactors : Analysis of Different Multiphase Models to Determine Oxygen Mass Transfer.” Chemie Ingenieur Technik, Wiley, 2020, p. 1324, https://doi.org/10.1002/cite.202055288.
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