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dc.contributor.authorSeidel, Stefan-
dc.contributor.authorWerner, Sören-
dc.contributor.authorEibl, Dieter-
dc.description.abstractOxygen supply of cells has a significant influence on cell growth and product yield. For this reason, biopharmaceutical manufacturers and their bioreactor suppliers are interested in optimizing the oxygen supply. In this context, computational fluid dynamics (CFD) can be used to calculate the kLa value in stirred bioreactors. First investigations have shown that both the volume-of-fluid (VOF) model and the compressible VOF model are unsuitable for the calculation of kLa values due to their lack of accuracy. Simulations with the Euler-Euler model showed significantly better agreement with experimental data, but the calculated kLa values were still about 50% higher than in the experiments. One reason could be the missing consideration of gas bubble breakup and coalescence. Therefore, various investigations were carried out with a population balance model (PBM)-coupled Euler-Euler model, which all were in better agreement with the experimental data, compared to the Euler-Euler model. With the help of the successfully established PBM-coupled CFD model it is now possible to calculate the oxygen mass transfer for stirred bioreactors. Thus, bioreactor and process design can be accomplished before prototyping, and time-consuming as well as cost-intensive laboratory experiments can be reduced. In order to verify the generality for all sizes of bioreactors, further validation work will be carried out.de_CH
dc.relation.ispartofChemie Ingenieur Technikde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectCFD simulationde_CH
dc.subjectMultiphase modelingde_CH
dc.subjectOxygen transfer ratede_CH
dc.subjectPopulation balance modelingde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleCFD for stirred bioreactors : analysis of different multiphase models to determine oxygen mass transferde_CH
dc.typeKonferenz: Posterde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.conference.details10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 : Processes for Future, Web-Konferenz, 21.-24. September 2020de_CH
zhaw.publication.reviewNot specifiedde_CH
zhaw.title.proceedingsSpecial Issue : 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020de_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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