| Publikationstyp: | Konferenz: Poster |
| Art der Begutachtung: | Peer review (Abstract) |
| Titel: | Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD |
| Autor/-in: | Schenk, A Ziegler, LN Meier, Nadja Peter, Samuel Wolfram, Evelyn |
| DOI: | 10.1055/s-0037-1608215 |
| Erschienen in: | Planta Medica International Open |
| Band(Heft): | 4 |
| Angaben zur Konferenz: | 65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), Basel, 3-6 September 2017 |
| Erscheinungsdatum: | 24-Okt-2017 |
| Verlag / Hrsg. Institution: | Thieme |
| ISSN: | 2509-6656 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 572: Biochemie 615: Pharmakologie und Therapeutik 660.6: Biotechnologie |
| Zusammenfassung: | Using a coreshell column, the new UHPLC-DAD method allows almost a baseline separation of seven sennosides and the monomeric hydroxyanthracene glycosides rhein 8-glycoside and aloe emodin 8-glycoside in senna pod dry extract and in a senna-fig syrup preparation. UV and mass spectrometry studies show that none of the peaks of interest is underlaid by flavonoids, a fact which, in the case of other LC methods for sennosides, requires a sample processing by means of SPE. Sennosides are determined by sennoside B, monomeric hydroyanthracene glycosides by rhein 8-glycoside as external standard. The combined determination of all hyrdoxyanthracene glycosides is important for pharmaceutical stability testing because sennosides are partly degraded to rhein- and aloe emodin 8-glycoside. In the posterior part of the chromatogram the aglycones rhein and aloe emodine can be determined. The complete assay runs 19 min. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/1964 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Schenk, A., Ziegler, L., Meier, N., Peter, S., & Wolfram, E. (2017). Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD [Conference poster]. Planta Medica International Open, 4. https://doi.org/10.1055/s-0037-1608215
Schenk, A. et al. (2017) ‘Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD’, in Planta Medica International Open. Thieme. Available at: https://doi.org/10.1055/s-0037-1608215.
A. Schenk, L. Ziegler, N. Meier, S. Peter, and E. Wolfram, “Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD,” in Planta Medica International Open, Oct. 2017, vol. 4. doi: 10.1055/s-0037-1608215.
SCHENK, A, LN ZIEGLER, Nadja MEIER, Samuel PETER und Evelyn WOLFRAM, 2017. Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD. In: Planta Medica International Open. Conference poster. Thieme. 24 Oktober 2017
Schenk, A, LN Ziegler, Nadja Meier, Samuel Peter, and Evelyn Wolfram. 2017. “Combined Determination of Sennosides, Monomeric Hydroxyanthacene Glycosides and Anthraquinone Aglycones by UHPLC-DAD.” Conference poster. In Planta Medica International Open. Vol. 4. Thieme. https://doi.org/10.1055/s-0037-1608215.
Schenk, A., et al. “Combined Determination of Sennosides, Monomeric Hydroxyanthacene Glycosides and Anthraquinone Aglycones by UHPLC-DAD.” Planta Medica International Open, vol. 4, Thieme, 2017, https://doi.org/10.1055/s-0037-1608215.
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