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dc.contributor.authorSchenk, A-
dc.contributor.authorZiegler, LN-
dc.contributor.authorMeier, Nadja-
dc.contributor.authorPeter, Samuel-
dc.contributor.authorWolfram, Evelyn-
dc.date.accessioned2018-01-10T13:00:10Z-
dc.date.available2018-01-10T13:00:10Z-
dc.date.issued2017-10-24-
dc.identifier.issn2509-6656de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/1964-
dc.description.abstractUsing a coreshell column, the new UHPLC-DAD method allows almost a baseline separation of seven sennosides and the monomeric hydroxyanthracene glycosides rhein 8-glycoside and aloe emodin 8-glycoside in senna pod dry extract and in a senna-fig syrup preparation. UV and mass spectrometry studies show that none of the peaks of interest is underlaid by flavonoids, a fact which, in the case of other LC methods for sennosides, requires a sample processing by means of SPE. Sennosides are determined by sennoside B, monomeric hydroyanthracene glycosides by rhein 8-glycoside as external standard. The combined determination of all hyrdoxyanthracene glycosides is important for pharmaceutical stability testing because sennosides are partly degraded to rhein- and aloe emodin 8-glycoside. In the posterior part of the chromatogram the aglycones rhein and aloe emodine can be determined. The complete assay runs 19 min.de_CH
dc.language.isoende_CH
dc.publisherThiemede_CH
dc.relation.ispartofPlanta Medica International Opende_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.subject.ddc660.6: Biotechnologiede_CH
dc.titleCombined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DADde_CH
dc.typeKonferenz: Posterde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1055/s-0037-1608215de_CH
zhaw.conference.details65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), Basel, 3-6 September 2017de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume4de_CH
zhaw.publication.reviewPeer review (Abstract)de_CH
zhaw.webfeedPhytopharmaziede_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Schenk, A., Ziegler, L., Meier, N., Peter, S., & Wolfram, E. (2017). Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD [Conference poster]. Planta Medica International Open, 4. https://doi.org/10.1055/s-0037-1608215
Schenk, A. et al. (2017) ‘Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD’, in Planta Medica International Open. Thieme. Available at: https://doi.org/10.1055/s-0037-1608215.
A. Schenk, L. Ziegler, N. Meier, S. Peter, and E. Wolfram, “Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD,” in Planta Medica International Open, Oct. 2017, vol. 4. doi: 10.1055/s-0037-1608215.
SCHENK, A, LN ZIEGLER, Nadja MEIER, Samuel PETER und Evelyn WOLFRAM, 2017. Combined determination of sennosides, monomeric hydroxyanthacene glycosides and anthraquinone aglycones by UHPLC-DAD. In: Planta Medica International Open. Conference poster. Thieme. 24 Oktober 2017
Schenk, A, LN Ziegler, Nadja Meier, Samuel Peter, and Evelyn Wolfram. 2017. “Combined Determination of Sennosides, Monomeric Hydroxyanthacene Glycosides and Anthraquinone Aglycones by UHPLC-DAD.” Conference poster. In Planta Medica International Open. Vol. 4. Thieme. https://doi.org/10.1055/s-0037-1608215.
Schenk, A., et al. “Combined Determination of Sennosides, Monomeric Hydroxyanthacene Glycosides and Anthraquinone Aglycones by UHPLC-DAD.” Planta Medica International Open, vol. 4, Thieme, 2017, https://doi.org/10.1055/s-0037-1608215.


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