Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-18730
Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications
Authors : Wuillemin, Michel A.
Reber, Michael
Fox, Thomas
Spingler, Bernhard
Brühwiler, Dominik
Alberto, Roger
Braband, Henrik
et. al : No
DOI : 10.3390/inorganics7110134
10.21256/zhaw-18730
Published in : Inorganics
Volume(Issue) : 7
Issue : 11
Pages : 134
Issue Date: 2019
Publisher / Ed. Institution : MDPI
ISSN: 2304-6740
Language : English
Subjects : Technetium; Rhenium; Complexes; Mesoporous silica; MCM-41; SBA-15; Theranostic; Radioprobe
Subject (DDC) : 540: Chemistry
Abstract: Taking advantage of the radiation properties of 99mTc and 186/188Re and the photophysical characteristics of the {M(CO)3}+ moiety (M = Re), we developed a multifunctional silica platform with the theranostic pair 99mTc/Re with high potential for (nano)medical applications. Starting with a general screening to evaluate the most suitable mesoporous silica construct and the development of appropriate chelate systems, multifunctional mesoporous silica microparticles (SBA-15) were synthesized. These particles act as a model towards the synthesis of the corresponding nanoconstructs. The particles can be modified at the external surface with a targeting function and labeled with the {M(CO)3}+ moiety (M = 99mTc, Re) at the pore surface. Thus, a silica platform is realized, whose bioprofile is not altered by the loaded modalities. The described synthetic procedures can be applied to establish a target-specific theranostic nanoplatform, which enables the combination of fluorescence and radio imaging, with the possibility of radio- and chemotherapy.
URI: https://digitalcollection.zhaw.ch/handle/11475/18730
Fulltext version : Published version
License (according to publishing contract) : CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in Collections:Publikationen Life Sciences und Facility Management

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