1. ZHAW digitalcollection
  2. Life Sciences und Facility Management
  3. Publikationen
  4. Publikationen Life Sciences und Facility Management
Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-18730
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWuillemin, Michel A.-
dc.contributor.authorReber, Michael-
dc.contributor.authorFox, Thomas-
dc.contributor.authorSpingler, Bernhard-
dc.contributor.authorBrühwiler, Dominik-
dc.contributor.authorAlberto, Roger-
dc.contributor.authorBraband, Henrik-
dc.date.accessioned2019-11-14T15:46:12Z-
dc.date.available2019-11-14T15:46:12Z-
dc.date.issued2019-
dc.identifier.issn2304-6740de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/18730-
dc.description.abstractTaking advantage of the radiation properties of 99mTc and 186/188Re and the photophysical characteristics of the {M(CO)3}+ moiety (M = Re), we developed a multifunctional silica platform with the theranostic pair 99mTc/Re with high potential for (nano)medical applications. Starting with a general screening to evaluate the most suitable mesoporous silica construct and the development of appropriate chelate systems, multifunctional mesoporous silica microparticles (SBA-15) were synthesized. These particles act as a model towards the synthesis of the corresponding nanoconstructs. The particles can be modified at the external surface with a targeting function and labeled with the {M(CO)3}+ moiety (M = 99mTc, Re) at the pore surface. Thus, a silica platform is realized, whose bioprofile is not altered by the loaded modalities. The described synthetic procedures can be applied to establish a target-specific theranostic nanoplatform, which enables the combination of fluorescence and radio imaging, with the possibility of radio- and chemotherapy.de_CH
dc.language.isoende_CH
dc.publisherMDPIde_CH
dc.relation.ispartofInorganicsde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectTechnetiumde_CH
dc.subjectRheniumde_CH
dc.subjectComplexesde_CH
dc.subjectMesoporous silicade_CH
dc.subjectMCM-41de_CH
dc.subjectSBA-15de_CH
dc.subjectTheranosticde_CH
dc.subjectRadioprobede_CH
dc.subject.ddc540: Chemiede_CH
dc.titleTowards 99mTc- and Re-based multifunctional silica platforms for theranostic applicationsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.3390/inorganics7110134de_CH
dc.identifier.doi10.21256/zhaw-18730-
zhaw.funding.euNode_CH
zhaw.issue11de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start134de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume7de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.funding.snf172805de_CH
zhaw.webfeedPolymerchemiede_CH
zhaw.author.additionalNode_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
File Description SizeFormat 
2019Wuillemin-etal_inorganics-07-00134.pdf3.44 MBAdobe PDFThumbnail
View/Open
Show simple item record
Wuillemin, M. A., Reber, M., Fox, T., Spingler, B., Brühwiler, D., Alberto, R., & Braband, H. (2019). Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications. Inorganics, 7(11), 134. https://doi.org/10.3390/inorganics7110134
Wuillemin, M.A. et al. (2019) ‘Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications’, Inorganics, 7(11), p. 134. Available at: https://doi.org/10.3390/inorganics7110134.
M. A. Wuillemin et al., “Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications,” Inorganics, vol. 7, no. 11, p. 134, 2019, doi: 10.3390/inorganics7110134.
WUILLEMIN, Michel A., Michael REBER, Thomas FOX, Bernhard SPINGLER, Dominik BRÜHWILER, Roger ALBERTO und Henrik BRABAND, 2019. Towards 99mTc- and Re-based multifunctional silica platforms for theranostic applications. Inorganics. 2019. Bd. 7, Nr. 11, S. 134. DOI 10.3390/inorganics7110134
Wuillemin, Michel A., Michael Reber, Thomas Fox, Bernhard Spingler, Dominik Brühwiler, Roger Alberto, and Henrik Braband. 2019. “Towards 99mTc- and Re-Based Multifunctional Silica Platforms for Theranostic Applications.” Inorganics 7 (11): 134. https://doi.org/10.3390/inorganics7110134.
Wuillemin, Michel A., et al. “Towards 99mTc- and Re-Based Multifunctional Silica Platforms for Theranostic Applications.” Inorganics, vol. 7, no. 11, 2019, p. 134, https://doi.org/10.3390/inorganics7110134.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.