Publikationstyp: Konferenz: Sonstiges
Art der Begutachtung: Keine Angabe
Titel: A bioreactor system for mechanical stimulation allows in vitro studies simulating in vivo conditions as close as possible
Autor/-in: Wohlwend, Lorenz
Mathes, Stephanie
von Mentlen, Roger
Graf-Hausner, Ursula
Angaben zur Konferenz: 3rd International Symposium «Interface Biology of Implants», Rostock, Germany, 12-14 May 2009
Erscheinungsdatum: 2009
Sprache: Englisch
Schlagwörter: Regeneration; Tissue; Bioreactor
Fachgebiet (DDC): 660: Technische Chemie
Zusammenfassung: Physical forces play an essential role in the proliferation and differentiation of many cell types, including fibroblasts and chondrocytes. The expression of certain genes for the formation of extracellular matrix, such as tenascin-c, is directly related to mechanical forces applied to the cells. Therefore in vitro studies under static conditions are limited. The development of biomaterials and cell based therapies could be enhanced by using a bioreactor system which performs perfusion and biomechanical stimulation during cell proliferation and differentiation. Recent investigations of biomaterials comparing static and dynamic cultivation systems showed clearly a significant difference concerning the expression of extracellular matrix proteins, the stability and the elasticity of the materials. As an example the pressure and shear forces of wound tissue were applied in order to develop an implant material for gingival soft tissue augmentation.
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): Lizenz gemäss Verlagsvertrag
Departement: School of Engineering
Organisationseinheit: Institut für Chemie und Biotechnologie (ICBT)
Institut für Mechanische Systeme (IMES)
Enthalten in den Sammlungen:Publikationen School of Engineering

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