Publication type: Conference other
Type of review: Not specified
Title: A bioreactor system for mechanical stimulation allows in vitro studies simulating in vivo conditions as close as possible
Authors: Wohlwend, Lorenz
Mathes, Stephanie
von Mentlen, Roger
Graf-Hausner, Ursula
Conference details: 3rd International Symposium «Interface Biology of Implants», Rostock, Germany, 12-14 May 2009
Issue Date: 2009
Language: English
Subjects: Regeneration; Tissue; Bioreactor
Subject (DDC): 660: Chemical engineering
Abstract: Physical forces play an essential role in the proliferation and differentiation of many cell types, including fibroblasts and chondrocytes. The expression of certain genes for the formation of extracellular matrix, such as tenascin-c, is directly related to mechanical forces applied to the cells. Therefore in vitro studies under static conditions are limited. The development of biomaterials and cell based therapies could be enhanced by using a bioreactor system which performs perfusion and biomechanical stimulation during cell proliferation and differentiation. Recent investigations of biomaterials comparing static and dynamic cultivation systems showed clearly a significant difference concerning the expression of extracellular matrix proteins, the stability and the elasticity of the materials. As an example the pressure and shear forces of wound tissue were applied in order to develop an implant material for gingival soft tissue augmentation.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: School of Engineering
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Institute of Mechanical Systems (IMES)
Appears in collections:Publikationen School of Engineering

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