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dc.contributor.authorWohlwend, Lorenz-
dc.contributor.authorMathes, Stephanie-
dc.contributor.authorvon Mentlen, Roger-
dc.contributor.authorGraf-Hausner, Ursula-
dc.date.accessioned2019-04-24T12:58:05Z-
dc.date.available2019-04-24T12:58:05Z-
dc.date.issued2009-
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/16863-
dc.description.abstractPhysical forces play an essential role in the proliferation and differentiation of many cell types, including fibroblasts and chondrocytes. The expression of certain genes for the formation of extracellular matrix, such as tenascin-c, is directly related to mechanical forces applied to the cells. Therefore in vitro studies under static conditions are limited. The development of biomaterials and cell based therapies could be enhanced by using a bioreactor system which performs perfusion and biomechanical stimulation during cell proliferation and differentiation. Recent investigations of biomaterials comparing static and dynamic cultivation systems showed clearly a significant difference concerning the expression of extracellular matrix proteins, the stability and the elasticity of the materials. As an example the pressure and shear forces of wound tissue were applied in order to develop an implant material for gingival soft tissue augmentation.de_CH
dc.language.isoende_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectRegenerationde_CH
dc.subjectTissuede_CH
dc.subjectBioreactorde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleA bioreactor system for mechanical stimulation allows in vitro studies simulating in vivo conditions as close as possiblede_CH
dc.typeKonferenz: Sonstigesde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.organisationalunitInstitut für Mechanische Systeme (IMES)de_CH
zhaw.conference.details3rd International Symposium «Interface Biology of Implants», Rostock, Germany, 12-14 May 2009de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewNot specifiedde_CH
Appears in Collections:Publikationen School of Engineering

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