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Title: Gene expression signatures of pathways alterations in tumor cells caused by plant extracts
Authors : Wagschal, Isabelle
Eggenschwiler, Jenny
von Balthazar, Leopold
Patrignani, Andrea
Rehrauer, Hubert
Schlapbach, Ralph
Ramos, Mac H.
Viviani, Angelika
Published in : Medicina (Buenos Aires)
Volume(Issue) : 67
Issue : Suppl. II
Pages : 97
Pages to: 106
Conference details: International Symposium: New Directions in Cancer Management, Academia Nacional de Medicina, Buenos Aires, Argentina, 6 - 8 June 2007
Publisher / Ed. Institution : Fundación Revista Medicina
Issue Date: 2007
License (according to publishing contract) : CC BY 4.0: Attribution 4.0 International
Type of review: Not specified
Language : English
Subject (DDC) : 616: Internal medicine and diseases
Abstract: Extracts of Viscum album from different host trees (Iscador®Qu, M, P and A) and isolated mistletoe lectin showed distinct gene-expression profiles using cDNA microarrays. We were able to confirm that genes of apoptosis, the cell cycle and the immune system were affected by mistletoe preparations and we also found that signal transduction, cell communication and cancer related pathways were overregulated in the tested breast cancer (HCC-1937, MCF-7, KPL-1, Mfm-223) and lymphoma cell lines (WSZ-NHL). The effect of a specific mistletoe extract on a particular cell line was individual, so that the distinction between the reaction of the cell type and/or the influence of the mistletoe preparation could be used in targeted mistletoe therapy.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Conference Paper
DOI : 10.21256/zhaw-2770
ISSN: 0025-7680
Appears in Collections:Publikationen Life Sciences und Facility Management

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