Gene expression signatures of pathways alterations in tumor cells caused by plant extracts

Wagschal, Isabelle; Eggenschwiler, Jenny; von Balthazar, Leopold; Patrignani, Andrea; Rehrauer, Hubert; Schlapbach, Ralph; Ramos, Mac H.; Viviani, Angelika

doi:10.21256/zhaw-2770

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-2770

Publication type:	Conference paper
Type of review:	Not specified
Title:	Gene expression signatures of pathways alterations in tumor cells caused by plant extracts
Authors:	Wagschal, Isabelle Eggenschwiler, Jenny von Balthazar, Leopold Patrignani, Andrea Rehrauer, Hubert Schlapbach, Ralph Ramos, Mac H. Viviani, Angelika
DOI:	10.21256/zhaw-2770
Published in:	Medicina
Volume(Issue):	67
Issue:	Suppl. II
Page(s):	97
Pages to:	106
Conference details:	International Symposium: New Directions in Cancer Management, Academia Nacional de Medicina, Buenos Aires, Argentina, 6-8 June 2007
Issue Date:	2007
Publisher / Ed. Institution:	Fundación Revista Medicina
ISSN:	0025-7680 1669-9106
Language:	English
Subject (DDC):	616: Internal medicine and diseases
Abstract:	Extracts of Viscum album from different host trees (Iscador®Qu, M, P and A) and isolated mistletoe lectin showed distinct gene-expression profiles using cDNA microarrays. We were able to confirm that genes of apoptosis, the cell cycle and the immune system were affected by mistletoe preparations and we also found that signal transduction, cell communication and cancer related pathways were overregulated in the tested breast cancer (HCC-1937, MCF-7, KPL-1, Mfm-223) and lymphoma cell lines (WSZ-NHL). The effect of a specific mistletoe extract on a particular cell line was individual, so that the distinction between the reaction of the cell type and/or the influence of the mistletoe preparation could be used in targeted mistletoe therapy.
URI:	https://digitalcollection.zhaw.ch/handle/11475/15010
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Wagschal, I., Eggenschwiler, J., von Balthazar, L., Patrignani, A., Rehrauer, H., Schlapbach, R., Ramos, M. H., & Viviani, A. (2007). Gene expression signatures of pathways alterations in tumor cells caused by plant extracts [Conference paper]. Medicina, 67(Suppl. II), 97–106. https://doi.org/10.21256/zhaw-2770

Wagschal, I. et al. (2007) ‘Gene expression signatures of pathways alterations in tumor cells caused by plant extracts’, in Medicina. Fundación Revista Medicina, pp. 97–106. Available at: https://doi.org/10.21256/zhaw-2770.

I. Wagschal et al., “Gene expression signatures of pathways alterations in tumor cells caused by plant extracts,” in Medicina, 2007, vol. 67, no. Suppl. II, pp. 97–106. doi: 10.21256/zhaw-2770.

WAGSCHAL, Isabelle, Jenny EGGENSCHWILER, Leopold VON BALTHAZAR, Andrea PATRIGNANI, Hubert REHRAUER, Ralph SCHLAPBACH, Mac H. RAMOS und Angelika VIVIANI, 2007. Gene expression signatures of pathways alterations in tumor cells caused by plant extracts. In: Medicina. Conference paper. Fundación Revista Medicina. 2007. S. 97–106

Wagschal, Isabelle, Jenny Eggenschwiler, Leopold von Balthazar, Andrea Patrignani, Hubert Rehrauer, Ralph Schlapbach, Mac H. Ramos, and Angelika Viviani. 2007. “Gene Expression Signatures of Pathways Alterations in Tumor Cells Caused by Plant Extracts.” Conference paper. In Medicina, 67:97–106. Fundación Revista Medicina. https://doi.org/10.21256/zhaw-2770.

Wagschal, Isabelle, et al. “Gene Expression Signatures of Pathways Alterations in Tumor Cells Caused by Plant Extracts.” Medicina, vol. 67, no. Suppl. II, Fundación Revista Medicina, 2007, pp. 97–106, https://doi.org/10.21256/zhaw-2770.