Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Stable reprogramming of brain transcription profiles by the early social environment in a cooperatively breeding fish
Authors: Taborsky, Barbara
Tschirren, Linda
Meunier, Clémence
Aubin-Horth, Nadia
DOI: 10.1098/rspb.2012.2605
Published in: Proceedings of the Royal Society B
Volume(Issue): 280
Issue: 1753
Issue Date: 2013
Publisher / Ed. Institution: The Royal Society Publishing
ISSN: 0962-8452
Language: English
Subjects: Animals; Brain; Cichlids; Corticotropin-Releasing Hormone; Female; Fish Proteins; Male; Molecular Sequence Data; RNA, Messenger; Real-Time Polymerase Chain Reaction; Receptors, Steroid; Sequence Analysis, DNA; Stress, Physiological; Gene Expression Regulation; Social Behavior
Subject (DDC): 572: Biochemistry
Abstract: Adult social behaviour can be persistently modified by early-life social experience. In rodents, such effects are induced by tactile maternal stimulation resulting in neuroendocrine modifications of the hypothalamic-pituitary-adrenal axis involved in stress responsiveness. Whether similar long-term alterations can occur in the hypothalamic-pituitary-interrenal (HPI) axis of poikilothermic vertebrates is unknown. We compared the expression of four genes of the HPI axis in adults of the cooperatively breeding cichlid Neolamprologus pulcher, which had been exposed to two early-life social treatments 1.5 years prior to brain sampling. Fish reared with parents and siblings had less brain expression of corticotropin-releasing factor and of the functional homologue of the mammalian glucocorticoid receptor (GR1) than individuals reared with same-age siblings only. Expression of the mineralocorticoid receptors (MR) did not differ between treatments, but the MR/GR1 expression ratio was markedly higher in fish reared with parents and siblings. Thus, we show here that early social experience can alter the programming of the stress axis in poikilothermic vertebrates, suggesting that this mechanism is deeply conserved within vertebrates. Moreover, we show for the first time that reprogramming of the stress axis of a vertebrate can be induced without tactile stimulation by parents.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Natural Resource Sciences (IUNR)
Appears in Collections:Publikationen Life Sciences und Facility Management

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.