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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3860
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dc.contributor.authorBliven, Spencer E.-
dc.contributor.authorLafita, Aleix-
dc.contributor.authorRose, Peter W.-
dc.contributor.authorCapitani, Guido-
dc.contributor.authorPrlić, Andreas-
dc.contributor.authorBourne, Philip E.-
dc.date.accessioned2018-07-12T13:17:30Z-
dc.date.available2018-07-12T13:17:30Z-
dc.date.issued2018-04-09-
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/7969-
dc.descriptionNow published in PLOS Computational Biology doi:10.1371/journal.pcbi.1006842de_CH
dc.description.abstractMany proteins fold into highly regular and repetitive three dimensional structures. The analysis of structural patterns and repeated elements is fundamental to understand protein function and evolution. We present recent improvements to the CE-Symm tool for systematically detecting and analyzing the internal symmetry and structural repeats in proteins. In addition to the accurate detection of internal symmetry, the tool is now capable of i) reporting the type of symmetry, ii) identifying the smallest repeating unit, iii) describing the arrangement of repeats with transformation operations and symmetry axes, and iv) comparing the similarity of all the internal repeats at the residue level. CE-Symm 2.0 helps the user investigate proteins with a robust and intuitive sequence-to-structure analysis, with many applications in protein classification, functional annotation and evolutionary studies. We describe the algorithmic extensions of the method and demonstrate its applications to the study of interesting cases of protein evolution.de_CH
dc.format.extent21de_CH
dc.language.isoende_CH
dc.publisherbioRxivde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleAnalyzing the symmetrical arrangement of structural repeats in proteins with CE-Symmde_CH
dc.typeWeiteres (textuelles Material)de_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1101/297960de_CH
dc.identifier.doi10.21256/zhaw-3860-
zhaw.funding.euNot specifiedde_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statussubmittedVersionde_CH
zhaw.funding.snf174836de_CH
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Bliven, S. E., Lafita, A., Rose, P. W., Capitani, G., Prlić, A., & Bourne, P. E. (2018). Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm. bioRxiv. https://doi.org/10.1101/297960
Bliven, S.E. et al. (2018) Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm. bioRxiv. Available at: https://doi.org/10.1101/297960.
S. E. Bliven, A. Lafita, P. W. Rose, G. Capitani, A. Prlić, and P. E. Bourne, Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm. bioRxiv, 2018. doi: 10.1101/297960.
BLIVEN, Spencer E., Aleix LAFITA, Peter W. ROSE, Guido CAPITANI, Andreas PRLIĆ und Philip E. BOURNE, 2018. Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm. bioRxiv
Bliven, Spencer E., Aleix Lafita, Peter W. Rose, Guido Capitani, Andreas Prlić, and Philip E. Bourne. 2018. Analyzing the Symmetrical Arrangement of Structural Repeats in Proteins with CE-Symm. bioRxiv. https://doi.org/10.1101/297960.
Bliven, Spencer E., et al. Analyzing the Symmetrical Arrangement of Structural Repeats in Proteins with CE-Symm. bioRxiv, 2018, https://doi.org/10.1101/297960.


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