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https://doi.org/10.21256/zhaw-3860| Publikationstyp: | Weiteres (textuelles Material) |
| Titel: | Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm |
| Autor/-in: | Bliven, Spencer E. Lafita, Aleix Rose, Peter W. Capitani, Guido Prlić, Andreas Bourne, Philip E. |
| DOI: | 10.1101/297960 10.21256/zhaw-3860 |
| Umfang: | 21 |
| Erscheinungsdatum: | 9-Apr-2018 |
| Verlag / Hrsg. Institution: | bioRxiv |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 572: Biochemie |
| Zusammenfassung: | Many proteins fold into highly regular and repetitive three dimensional structures. The analysis of structural patterns and repeated elements is fundamental to understand protein function and evolution. We present recent improvements to the CE-Symm tool for systematically detecting and analyzing the internal symmetry and structural repeats in proteins. In addition to the accurate detection of internal symmetry, the tool is now capable of i) reporting the type of symmetry, ii) identifying the smallest repeating unit, iii) describing the arrangement of repeats with transformation operations and symmetry axes, and iv) comparing the similarity of all the internal repeats at the residue level. CE-Symm 2.0 helps the user investigate proteins with a robust and intuitive sequence-to-structure analysis, with many applications in protein classification, functional annotation and evolutionary studies. We describe the algorithmic extensions of the method and demonstrate its applications to the study of interesting cases of protein evolution. |
| Weitere Angaben: | Now published in PLOS Computational Biology doi:10.1371/journal.pcbi.1006842 |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/7969 |
| Volltext Version: | Eingereichte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Computational Life Sciences (ICLS) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2018-05-18 CE-Symm Preprint.pdf | 4.59 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Bliven, S. E., Lafita, A., Rose, P. W., Capitani, G., Prlić, A., & Bourne, P. E. (2018). Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm. bioRxiv. https://doi.org/10.1101/297960
Bliven, S.E. et al. (2018) Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm. bioRxiv. Available at: https://doi.org/10.1101/297960.
S. E. Bliven, A. Lafita, P. W. Rose, G. Capitani, A. Prlić, and P. E. Bourne, Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm. bioRxiv, 2018. doi: 10.1101/297960.
BLIVEN, Spencer E., Aleix LAFITA, Peter W. ROSE, Guido CAPITANI, Andreas PRLIĆ und Philip E. BOURNE, 2018. Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm. bioRxiv
Bliven, Spencer E., Aleix Lafita, Peter W. Rose, Guido Capitani, Andreas Prlić, and Philip E. Bourne. 2018. Analyzing the Symmetrical Arrangement of Structural Repeats in Proteins with CE-Symm. bioRxiv. https://doi.org/10.1101/297960.
Bliven, Spencer E., et al. Analyzing the Symmetrical Arrangement of Structural Repeats in Proteins with CE-Symm. bioRxiv, 2018, https://doi.org/10.1101/297960.
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