Title: Novel hyperthermia applicator system allows adaptive treatment planning : preliminary clinical results in tumour-bearing animals
Authors : Dressel, S.
Gosselin, M.-C.
Capstick, M. H.
Carrasco, E.
Weyland, Mathias
Scheidegger, Stephan
Neufeld, E.
Kuster, N.
Bodis, S.
Rohrer Bley, C.
Published in : Veterinary and Comparative Oncology
Volume(Issue) : 16
Issue : 2
Pages : 202
Pages to: 213
Publisher / Ed. Institution : Wiley
Issue Date: 2017
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : adaptive treatment planning; Cat; Dog; Hyperthermia; Radiation; Tumour
Subject (DDC) : 615: Pharmacology and therapeutics
630: Agriculture
Abstract: Hyperthermia (HT) as an adjuvant to radiation therapy (RT) is a multimodality treatment method to enhance therapeutic efficacy in different tumours. High demands are placed on the hardware and treatment planning software to guarantee adequately planned and applied HT treatments. The aim of this prospective study was to determine the effectiveness and safety of the novel HT system in tumour-bearing dogs and cats in terms of local response and toxicity as well as to compare planned with actual achieved data during heating. A novel applicator with a flexible number of elements and integrated closed-loop temperature feedback control system, and a tool for patient-specific treatment planning were used in a combined thermoradiotherapy protocol. Good agreement between predictions from planning and clinical outcome was found in 7 of 8 cases. Effective HT treatments were planned and verified with the novel system and provided improved quality of life in all but 1 patient. This individualized treatment planning and controlled heat exposure allows adaptive, flexible and safe HT treatments in palliatively treated animal patients.
Departement: School of Engineering
Publication type: Article in scientific Journal
DOI : 10.1111/vco.12340
ISSN: 14765810
URI: https://digitalcollection.zhaw.ch/handle/11475/4714
Appears in Collections:Publikationen School of Engineering

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